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A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids
- Source :
- Organic and Biomolecular Chemistry
- Publication Year :
- 2012
-
Abstract
- The design, synthesis and biological evaluation of a novel C, D-spirolactone analogue of paclitaxel is described. This is the first paclitaxel analogue without an oxetane D-ring that shows a significant cytotoxic effect (activity one order of magnitude lower than paclitaxel). More importantly, its cytotoxicity is a result of a different mechanism of action, involving mTOR inhibition-dependent autophagy instead of G(2)/M cell cycle arrest-dependent apoptosis.
Details
- Database :
- OAIster
- Journal :
- Organic and Biomolecular Chemistry
- Notes :
- Organic and Biomolecular Chemistry
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1132719756
- Document Type :
- Electronic Resource