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Enteric hyperoxaluria: a hidden cause of early renal graft failure in two successive transplants: spontaneous late graft recovery.

Authors :
UCL - MD/MINT - Département de médecine interne
UCL - MD/MNOP - Département de morphologie normale et pathologique
Cuvelier, Charles
Goffin, Eric
Cosyns, Jean-Pierre
Wauthier, Michel
Van Ypersele de Strihou, Charles
UCL - MD/MINT - Département de médecine interne
UCL - MD/MNOP - Département de morphologie normale et pathologique
Cuvelier, Charles
Goffin, Eric
Cosyns, Jean-Pierre
Wauthier, Michel
Van Ypersele de Strihou, Charles
Source :
American journal of kidney diseases : the official journal of the National Kidney Foundation, Vol. 40, no. 1, p. E3 (2002)
Publication Year :
2002

Abstract

A 37-year-old patient underwent two successive renal transplantations 7 months apart. He remained dialysis dependent. Early biopsy of both grafts revealed widespread calcium oxalate deposition suggestive of acute oxalate nephropathy. Several causes of oxalate nephropathy, including primary oxalosis and an increased intake of oxalic acid precursors, were excluded. Two years later, the identification of steatorrhea with radiologic signs of chronic pancreatitis led to the hypothesis of enteric hyperoxaluria. Surprisingly, 11 months after the second transplantation, graft function improved progressively allowing interruption of dialysis. Three years later, renal function is stable. The causes and prevention of acute oxalate-induced graft failure are highlighted. Subclinical evidence of enteric hyperoxaluria should be looked for and appropriate therapy instituted as early as possible. The possibility of a late recovery of renal function warrants attentive patience from attending physicians.

Details

Database :
OAIster
Journal :
American journal of kidney diseases : the official journal of the National Kidney Foundation, Vol. 40, no. 1, p. E3 (2002)
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1130575709
Document Type :
Electronic Resource