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Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism.

Authors :
UCL - SSS/DDUV - Institut de Duve
Pieretti, Simone
Haanstra, Jurgen R
Mazet, Muriel
Perozzo, Remo
Bergamini, Christian
Prati, Federica
Fato, Romana
Lenaz, Giorgio
Capranico, Giovanni
Brun, Reto
Bakker, Barbara M
Michels, Paulus
Scapozza, Leonardo
Bolognesi, Maria Laura
Cavalli, Andrea
UCL - SSS/DDUV - Institut de Duve
Pieretti, Simone
Haanstra, Jurgen R
Mazet, Muriel
Perozzo, Remo
Bergamini, Christian
Prati, Federica
Fato, Romana
Lenaz, Giorgio
Capranico, Giovanni
Brun, Reto
Bakker, Barbara M
Michels, Paulus
Scapozza, Leonardo
Bolognesi, Maria Laura
Cavalli, Andrea
Source :
PLoS Neglected Tropical Diseases, Vol. 7, no.1, p. e2012 (2013)
Publication Year :
2013

Abstract

Overall, B6 showed a multitarget mechanism of action, which provides a molecular explanation of its promising anti-trypanosomatid activity. Furthermore, the forward chemical genetics approach here applied may be viable in the molecular characterization of novel multitarget ligands.

Details

Database :
OAIster
Journal :
PLoS Neglected Tropical Diseases, Vol. 7, no.1, p. e2012 (2013)
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1130506663
Document Type :
Electronic Resource