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A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS).

Authors :
UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
UCL - (SLuc) Service de rhumatologie
van Vollenhoven, Ronald
Voskuyl, Alexandre
Bertsias, George
Aranow, Cynthia
Aringer, Martin
Arnaud, Laurent
Askanase, Anca
Balážová, Petra
Bonfa, Eloisa
Bootsma, Hendrika
Boumpas, Dimitrios
Bruce, Ian
Cervera, Ricard
Clarke, Ann
Coney, Cindy
Costedoat-Chalumeau, Nathalie
Czirják, László
Derksen, Ronald
Doria, Andrea
Dörner, Thomas
Fischer-Betz, Rebecca
Fritsch-Stork, Ruth
Gordon, Caroline
Graninger, Winfried
Györi, Noémi
Houssiau, Frédéric
Isenberg, David
Jacobsen, Soren
Jayne, David
Kuhn, Annegret
Le Guern, Veronique
Lerstrøm, Kirsten
Levy, Roger
Machado-Ribeiro, Francinne
Mariette, Xavier
Missaykeh, Jamil
Morand, Eric
Mosca, Marta
Inanc, Murat
Navarra, Sandra
Neumann, Irmgard
Olesinska, Marzena
Petri, Michelle
Rahman, Anisur
Rekvig, Ole Petter
Rovensky, Jozef
Shoenfeld, Yehuda
Smolen, Josef
Tincani, Angela
Urowitz, Murray
van Leeuw, Bernadette
Vasconcelos, Carlos
Voss, Anne
Werth, Victoria P
Zakharova, Helena
Zoma, Asad
Schneider, Matthias
Ward, Michael
UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
UCL - (SLuc) Service de rhumatologie
van Vollenhoven, Ronald
Voskuyl, Alexandre
Bertsias, George
Aranow, Cynthia
Aringer, Martin
Arnaud, Laurent
Askanase, Anca
Balážová, Petra
Bonfa, Eloisa
Bootsma, Hendrika
Boumpas, Dimitrios
Bruce, Ian
Cervera, Ricard
Clarke, Ann
Coney, Cindy
Costedoat-Chalumeau, Nathalie
Czirják, László
Derksen, Ronald
Doria, Andrea
Dörner, Thomas
Fischer-Betz, Rebecca
Fritsch-Stork, Ruth
Gordon, Caroline
Graninger, Winfried
Györi, Noémi
Houssiau, Frédéric
Isenberg, David
Jacobsen, Soren
Jayne, David
Kuhn, Annegret
Le Guern, Veronique
Lerstrøm, Kirsten
Levy, Roger
Machado-Ribeiro, Francinne
Mariette, Xavier
Missaykeh, Jamil
Morand, Eric
Mosca, Marta
Inanc, Murat
Navarra, Sandra
Neumann, Irmgard
Olesinska, Marzena
Petri, Michelle
Rahman, Anisur
Rekvig, Ole Petter
Rovensky, Jozef
Shoenfeld, Yehuda
Smolen, Josef
Tincani, Angela
Urowitz, Murray
van Leeuw, Bernadette
Vasconcelos, Carlos
Voss, Anne
Werth, Victoria P
Zakharova, Helena
Zoma, Asad
Schneider, Matthias
Ward, Michael
Source :
Annals of the Rheumatic Diseases, Vol. 76, no.3, p. 554-561 (2017)
Publication Year :
2017

Abstract

OBJECTIVES: Treat-to-target recommendations have identified 'remission' as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE. METHODS: An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%. RESULTS: The task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions:1. Definitions of remission will be worded as follows: remission in SLE is a durable state characterised by …………………. (reference to symptoms, signs, routine labs).2. For defining remission, a validated index must be used, for example, clinical systemic lupus erythematosus disease activity index (SLEDAI)=0, British Isles lupus assessment group (BILAG) 2004 D/E only, clinical European consensus lupus outcome measure (ECLAM)=0; with routine laboratory assessments included, and supplemented with physician's global assessment.3. Distinction is made between remission off and on therapy: remission off therapy requires the patient to be on no other treatment for SLE than maintenance antimalarials; and remission on therapy allows patients to be on stable maintenance antimalarials, low-dose corticosteroids (prednisone ≤5 mg/day), maintenance immunosuppressives and/or maintenance biologics.The task force also agreed that the most appropriate outcomes (dependent variables) for testing the prognostic value (construct validity) of potential remission definitions are: death, damage, flares and measures of health-related quality of life. CONCLUSIONS: The work of this international task force provides a framework for testing different definitions of remission against long-term outcomes.

Details

Database :
OAIster
Journal :
Annals of the Rheumatic Diseases, Vol. 76, no.3, p. 554-561 (2017)
Notes :
Ndonga
Publication Type :
Electronic Resource
Accession number :
edsoai.on1130461905
Document Type :
Electronic Resource