Enantio‐, Regio‐ and Chemoselective Copper‐Catalyzed 1,2‐Hydroborylation of Acylsilanes

The enantioselective synthesis of synthetically significant (  -hydroxyallyl)silanes, (  -hydroxyaryl)silanes and (  hydroxyalkyl)silanes is reported. The present copper-catalysed 1,2hydroborylation of acylsilanes affords the aforementioned products in high yields and high enantiomeric excesses. This robust and scalable additive-free catalytic system relies on the use of low copper(II) acetate and diphosphine ligand loadings at room temperature in the presence of a commercially available and bench stable hydride source.