Individualized Treatment Analysis Of Breast Cancer With Chronic Renal Failure

Wei Liu,1,2,* Jin-fu Peng,1,2,* Meng-jie Tang1 1Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, People’s Republic of China; 2Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha 410013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meng-jie TangHunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, People’s Republic of ChinaEmail tangmengjie@hnca.org.cnAbstract: We report the case of a breast cancer patient with chronic renal failure (CRF). The clinical pharmacist adjusted the chemotherapy regimen and dosage according to the patient’s renal function after reviewing the literature and analyzing the pharmacological and pharmacokinetic characteristics of the patient’s antineoplastic drugs. To the best of our knowledge, this is the first report of successful multimodal treatment of breast cancer in a patient with CRF in China. The purpose of this case report is to optimize breast cancer therapy in patients with CRF and provide a reference for clinicians and clinical pharmacists to use antineoplastic drugs rationally.Keywords: breast cancer, chronic renal failure, treatment regimen, dose adjustment