Reduction in hospitalisations for acute gastroenteritis-associated childhood seizures since introduction of rotavirus vaccination:A time-series and change-point analysis of hospital admissions in England

Introduction: The incidence of severe childhood diarrhoea has fallen substantially following the introduction of rotavirus vaccine in the UK in July 2013. Since children with rotavirus infection may experience febrile and afebrile seizures, we evaluated the impact of rotavirus vaccination on seizure hospitalisations in children in England. Methods: Using data from Hospital Episode Statistics, we employed interrupted time-series analyses to assess changes in monthly hospital admissions for seizures among children aged