Utilisation of injectable flurochromes for quantification of bone growth in a sheep tibial dynamic fixation model

This project examined the use of an augmented histological technique for bone tissue using fluorochrome labelling in a newly developed experimental sheep fracture model. The fracture model encompassed the surgical creation of an experimental fracture which was precisely controlled and independent of external mechanical forces in order to study the effect of the mechanical environment on fracture healing. This research outlined the development and a pilot study combining sequential fluorochrome labelling into the experimental fracture model as a means to enhance the histological analysis of fracture healing and guide development of improved fracture fixation and tissue engineering strategies.