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The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome.
- Source :
- Department of Medical Oncology Faculty Papers
- Publication Year :
- 2019
-
Abstract
- Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.
Details
- Database :
- OAIster
- Journal :
- Department of Medical Oncology Faculty Papers
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1112611560
- Document Type :
- Electronic Resource