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Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

Authors :
Lesseur, C
Diergaarde, B
Olshan, Af
Wünsch Filho, V
Ness, Ar
Liu, Guopeng
Lacko, M
Eluf Neto, J
Franceschi, S
Lagiou, P
Macfarlane, Gj
Richiardi, L
Boccia, Stefania
Polesel, J
Kjaerheim, K
Zaridze, D
Johansson, M
Menezes, Am
Curado, Mp
Robinson, M
Ahrens, W
Canova, C
Znaor, A
Castellsagué, X
Conway, Di
Holcátová, I
Mates, D
Vilensky, M
Healy, Cm
Szeszenia Dąbrowska, N
Fabiánová, E
Lissowska, J
Grandis, Jr
Weissler, Mc
Tajara, Eh
Nunes, Fd
de Carvalho, Mb
Thomas, S
Hung, Rj
Peters, Wh
Herrero, R
Cadoni, Gabriella
Bueno de Mesquita, Hb
Steffen, A
Agudo, A
Shangina, O
Xiao, X
Gaborieau, V
Chabrier, A
Anantharaman, D
Boffetta, Paolo
Amos, Ci
Mckay, Jd
Brennan, P. 1.
Boccia, Stefania (ORCID:0000-0002-1864-749X)
Cadoni, Gabriella (ORCID:0000-0001-8244-784X)
Lesseur, C
Diergaarde, B
Olshan, Af
Wünsch Filho, V
Ness, Ar
Liu, Guopeng
Lacko, M
Eluf Neto, J
Franceschi, S
Lagiou, P
Macfarlane, Gj
Richiardi, L
Boccia, Stefania
Polesel, J
Kjaerheim, K
Zaridze, D
Johansson, M
Menezes, Am
Curado, Mp
Robinson, M
Ahrens, W
Canova, C
Znaor, A
Castellsagué, X
Conway, Di
Holcátová, I
Mates, D
Vilensky, M
Healy, Cm
Szeszenia Dąbrowska, N
Fabiánová, E
Lissowska, J
Grandis, Jr
Weissler, Mc
Tajara, Eh
Nunes, Fd
de Carvalho, Mb
Thomas, S
Hung, Rj
Peters, Wh
Herrero, R
Cadoni, Gabriella
Bueno de Mesquita, Hb
Steffen, A
Agudo, A
Shangina, O
Xiao, X
Gaborieau, V
Chabrier, A
Anantharaman, D
Boffetta, Paolo
Amos, Ci
Mckay, Jd
Brennan, P. 1.
Boccia, Stefania (ORCID:0000-0002-1864-749X)
Cadoni, Gabriella (ORCID:0000-0001-8244-784X)
Publication Year :
2016

Abstract

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10−8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2–TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci—9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301–HLA-DQA1*0103–HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10−9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10−6) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1105029602
Document Type :
Electronic Resource