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Reduced-intensity conditioning allogeneic transplant in heavily pre-treated chronic lymphocytic leukaemia patients: a single centre experience

Authors :
Laurenti, Luca
Chiusolo, Patrizia
Tarnani, M
Balducci, Mario
Piccirillo, Nicola
Sora', Federica
Sica, Simona
Leone, G.
Laurenti, L (ORCID:0000-0002-8327-1396)
Chiusolo, Patrizia (ORCID:0000-0002-1355-1587)
Balducci, M (ORCID:0000-0003-0398-9726)
Piccirillo, Nicola (ORCID:0000-0002-1688-1987)
Sora', Federica (ORCID:0000-0002-9607-5298)
Sica, S (ORCID:0000-0003-2426-3465)
Laurenti, Luca
Chiusolo, Patrizia
Tarnani, M
Balducci, Mario
Piccirillo, Nicola
Sora', Federica
Sica, Simona
Leone, G.
Laurenti, L (ORCID:0000-0002-8327-1396)
Chiusolo, Patrizia (ORCID:0000-0002-1355-1587)
Balducci, M (ORCID:0000-0003-0398-9726)
Piccirillo, Nicola (ORCID:0000-0002-1688-1987)
Sora', Federica (ORCID:0000-0002-9607-5298)
Sica, S (ORCID:0000-0003-2426-3465)
Publication Year :
2011

Abstract

B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder characterized by a heterogeneous clinical course that can be predicted by an array of new biological prognostic parameters 1–4. Despite recent therapeutic advances (mainly based on the combination of immuno and chemotherapy) the only curative option, especially for high-risk CLL patients, is represented by allogeneic transplantation 5, 6. However, overall mortality in allotransplanted CLL patients who undergo myeloablative conditioning regimens ranges between 30 and 60% 7, 8. In an effort to reduce the high transplant-related-mortality (TRM) of these patients, several groups have investigated the feasibility and efficacy of non-myeloablative transplantation in this setting 9, 10. The largest study conducted so far confirmed the benefit of reduced-intensity conditioning (RIC) transplant in high-risk patients 11.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1105022936
Document Type :
Electronic Resource