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Hybrid artificial pancreas: islet transplantation inside membrane bioreactors

Authors :
Urso, A
Careddu, G
Ghirlanda, Giovanni
Catapano, G
Brisinda, Giuseppe
Ceriati, Franco
Bellantone, Rocco Domenico Alfonso
Doglietto, Gb
Crucitti, F.
Lombardi, Cp (ORCID:0000-0001-8910-6693)
Brisinda, Giuseppe (ORCID:0000-0001-8820-9471)
Bellantone, Rocco Domenico Alfonso (ORCID:0000-0002-0844-3469)
Urso, A
Careddu, G
Ghirlanda, Giovanni
Catapano, G
Brisinda, Giuseppe
Ceriati, Franco
Bellantone, Rocco Domenico Alfonso
Doglietto, Gb
Crucitti, F.
Lombardi, Cp (ORCID:0000-0001-8910-6693)
Brisinda, Giuseppe (ORCID:0000-0001-8820-9471)
Bellantone, Rocco Domenico Alfonso (ORCID:0000-0002-0844-3469)
Publication Year :
1992

Abstract

The use of pancreatic islet transplantation in membrane bioreactors put in vascular circuits aims at resetting the glucose homeostasis in diabetic or pancreatectomized patients, avoiding immune host rejection. Our experience was carried out at following stages: porcine pancreas explantation and enzymatic separation of endocrine tissue from exocrine fraction by collagenase; evaluation of islet functionality (culture tests); in vitro tests of the islets-bioreactor system, to assess the metabolic response to the glucose; in vivo evaluation to assay the haemodynamic behaviour. The trials showed a good metabolic bioreactor functionality and a decreasing incidence of coagulative problems.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1105002805
Document Type :
Electronic Resource