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Distinguishing score 0 from score 1+ in HER2 immunohistochemistry-negative breast cancer: clinical and pathobiological relevance
- Source :
- American Journal of Clinical Pathology, Vol. 140, no.4, p. 561-566 (2013)
- Publication Year :
- 2013
-
Abstract
- OBJECTIVES: To investigate the clinical and pathobiological significance of distinguishing score 0 and score 1+ within the group of immunohistochemistry (IHC)-negative invasive breast cancers. METHODS: We studied HER2 status using both IHC and fluorescence in situ hybridization (FISH) in 150 consecutive breast tumors submitted to our laboratory after a negative IHC result in local testing centers. RESULTS: We were able to discern a group of score 0 tumors that had a lower HER2 copy number than the group consisting of score 1+ tumors. In contrast with the group of score 1+ tumors, HER2 FISH was consistently negative for both copy number-based and ratio-based tumors without equivocal results. CONCLUSIONS: In a setting with stringent quality assurance, score 0 and score 1+ tumors emerge as distinct and clinically important subgroups within the HER2 IHC-negative population
Details
- Database :
- OAIster
- Journal :
- American Journal of Clinical Pathology, Vol. 140, no.4, p. 561-566 (2013)
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1104525112
- Document Type :
- Electronic Resource