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Occupational exposure to pesticides is associated with differential DNA methylation

Authors :
Plaat, D.A. (Diana) van der
Jong, K. (Kim) de
Vries, M. (Maaike) de
Diemen, C.C. (Cleo) van
Prokić, I. (Ivana)
Amin, N. (Najaf)
Kromhout, H. (Hans)
Vermeulen, R. (Roel)
Postma, D.S. (Dirkje)
Duijn, C.M. (Cornelia) van
Boezen, H.M. (Marike)
Vonk, J.M. (Judith)
Plaat, D.A. (Diana) van der
Jong, K. (Kim) de
Vries, M. (Maaike) de
Diemen, C.C. (Cleo) van
Prokić, I. (Ivana)
Amin, N. (Najaf)
Kromhout, H. (Hans)
Vermeulen, R. (Roel)
Postma, D.S. (Dirkje)
Duijn, C.M. (Cornelia) van
Boezen, H.M. (Marike)
Vonk, J.M. (Judith)
Publication Year :
2018

Abstract

Objectives Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between occupational exposure to pesticides and genome-wide DNA methylation sites. Methods 1561 subjects of LifeLines were included with either no (n=1392), low (n=108) or high (n=61) exposure to any type of pesticides (estimated based on current or last held job). Blood DNA methylation levels were measured using Illumina 450K arrays. Associations between pesticide exposure and 420 938 methylation sites (CpGs) were assessed using robust linear regression adjusted for appropriate confounders. In addition, we performed genome-wide stratified and interaction analyses by gender, smoking and airway obstruction status, and assessed associations between gene expression and methylation for genome-wide significant CpGs (n=2802). Results In total for all analyses, high p

Details

Database :
OAIster
Notes :
application/pdf, BMJ British medical journal vol. 75 no. 65, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1081018440
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1136.oemed-2017-104787