CURRENT UPDATES ON ANTI-DIABETIC THERAPY

Diabetes globally has become one of the chronic public health problems and is related to group of metabolic defects resulting due to defect in insulin secretion and its action. As the disease progress micro and macro vascular damage may lead to retinopathy, neuropathy, nephropathy and various cardiovascular like complications. It is estimated that by the year of 2030 about 439 million adults would be suffering from any form of diabetes. There are mainly two types of diabetes which is because of their occurrence rate. The current review covers the basic aspect of types of diabetes, insulin molecular, chemical basis, and its secretion, hypoglycemic drugs used and their mode of action, what are the recent advancement in terms of new drugs finding, and the herbal plants. Thus, the information will help researchers for development of combination medication which involve both recent medication and herbal medication for combating various complication associated with diabetes. Â KEY WORDS: Hyperglycemia, insulin, glucose, phyto-constituents.