Lysosomes ‘in control’: where lipids meet Inflammation in metabolic syndrome

Despite the increasing number of patients suffering from liver inflammation, an inflammatory response commonly seen in obesity and obesity-related metabolic syndrome, the mechanisms underlying this type of inflammation are largely unknown. Currently, there is no effective treatment available. The diagnosis is made by liver biopsy, a procedure associated with serious complications. This dissertation provides new insights into the mechanisms underlying liver inflammation associated with metabolic syndrome. It is shown that the hepatic inflammatory response is caused by oxidised lipid accumulation in macrophage lysosomes, which are cellular compartments situated in immune cells. This dissertation describes a new blood test which allows for easier and quicker diagnosis of patients. It is also shown that several new treatment methods are effective. Finally, it is proven that intestinal flora plays a pivotal role in metabolic syndrome.