Effects of Granulocyte-colony Stimulating Factor on Cardiac Remodeling after Myocardial Infarction

Background : Recent studies suggest that granulocyte colony-stimulating factor (G-CSF) may be beneficial in the treatment of myocardial infarction (MI). However, the effects of G-CSF on MI are still controversial and the molecular mechanism of G-CSF treatment for repair of the infarcted heart is not fully understood. / Methods : Mice were divided into three groups: Control, MI and MI treated with G-CSF. Four weeks after MI, we examined cardiac function by Doppler echocardiography and measured noninfarcted myocardial mRNA expression by northern blot analysis....