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Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

Authors :
Beaumont, R.N. (Robin N.)
Warrington, N.M. (Nicole)
Cavadino, A. (Alana)
Tyrrell, A.W.R.
Nodzenski, M. (Michael)
Horikoshi, M. (Momoko)
Geller, F. (Frank)
Myhre, R. (Ronny)
Richmond, R.C. (Rebecca C.)
Paternoster, L. (Lavinia)
Bradfield, J.P. (Jonathan)
Kreiner-Møller, E. (Eskil)
Huikari, V. (Ville)
Metrustry, S. (Sarah)
Lunetta, K.L. (Kathryn)
Painter, J.N. (Jodie N.)
Hottenga, J.J. (Jouke Jan)
Allard, C. (Catherine)
Barton, S.J. (Sheila)
Espinosa, A. (Ana)
Marsh, J.A. (Julie)
Potter, C. (Catherine)
Zhang, G. (Ge)
Ang, W.Q. (Wei)
Berry, D. (Diane)
Bouchard, L. (Luigi)
Das, S. (Shikta)
Hakonarson, H. (Hakon)
Heikkinen, J. (Jani)
Helgeland, Ø. (Øyvind)
Hocher, B. (Berthold)
Hofman, A. (Albert)
Inskip, H.M. (Hazel)
Jones, S.E. (Samuel E.)
Kogevinas, M. (Manolis)
Lind, P.A. (Penelope)
Marullo, L. (Letizia)
Medland, S.E. (Sarah)
Murray, A. (Anna)
Murray, J.C. (Jeffrey C.)
Njølstad, P.R. (Pa l R.)
Nohr, C. (Christian)
Reichetzeder, C. (Christoph)
Ring, S.M. (Susan)
Ruth, K.S. (Katherine S.)
Santa-Marina, L. (Loreto)
Scholtens, D.M. (Denise M.)
Sebert, S. (Sylvain)
Sengpiel, V. (Verena)
Tuke, M.A. (Marcus A.)
Vaudel, M. (Marc)
Weedon, M.N. (Michael)
Willemsen, G.A.H.M. (Gonneke)
Wood, A.R. (Andrew R.)
Yaghootkar, H. (Hanieh)
Muglia, L.J. (Louis J.)
Bartels, M. (Meike)
Relton, C.L. (Caroline)
Pennell, C.E. (Craig)
Chatzi, L. (Leda)
Estivill, X. (Xavier)
Holloway, J.W. (John W.)
Boomsma, D.I. (Dorret)
Montgomery, G.W. (Grant W.)
Murabito, J. (Joanne)
Spector, T.D. (Timothy)
Power, C. (Christine)
Järvelin, M.-R. (Marjo-Ritta)
Bisgaard, H. (Hans)
Grant, S.F.A. (Struan F.A.)
Sørensen, T.I.A. (Thorkild I.A.)
Jaddoe, V.W. (Vincent W.)
Jacobsson, B. (Bo)
Melbye, M. (Mads)
McCarthy, M.I. (Mark I.)
Hattersley, A.T. (Andrew)
Hayes, M.G. (M. Geoffrey)
Frayling, T.M. (Timothy)
Hivert, M.-F. (Marie-France)
Felix, J.F. (Janine)
Hyppönen, E. (Elina)
Lowe, W.L. (William L.)
Evans, D.M. (David M.)
Lawlor, D.A. (Debbie A.)
Feenstra, B. (Bjarke)
Freathy, R.M. (Rachel)
Beaumont, R.N. (Robin N.)
Warrington, N.M. (Nicole)
Cavadino, A. (Alana)
Tyrrell, A.W.R.
Nodzenski, M. (Michael)
Horikoshi, M. (Momoko)
Geller, F. (Frank)
Myhre, R. (Ronny)
Richmond, R.C. (Rebecca C.)
Paternoster, L. (Lavinia)
Bradfield, J.P. (Jonathan)
Kreiner-Møller, E. (Eskil)
Huikari, V. (Ville)
Metrustry, S. (Sarah)
Lunetta, K.L. (Kathryn)
Painter, J.N. (Jodie N.)
Hottenga, J.J. (Jouke Jan)
Allard, C. (Catherine)
Barton, S.J. (Sheila)
Espinosa, A. (Ana)
Marsh, J.A. (Julie)
Potter, C. (Catherine)
Zhang, G. (Ge)
Ang, W.Q. (Wei)
Berry, D. (Diane)
Bouchard, L. (Luigi)
Das, S. (Shikta)
Hakonarson, H. (Hakon)
Heikkinen, J. (Jani)
Helgeland, Ø. (Øyvind)
Hocher, B. (Berthold)
Hofman, A. (Albert)
Inskip, H.M. (Hazel)
Jones, S.E. (Samuel E.)
Kogevinas, M. (Manolis)
Lind, P.A. (Penelope)
Marullo, L. (Letizia)
Medland, S.E. (Sarah)
Murray, A. (Anna)
Murray, J.C. (Jeffrey C.)
Njølstad, P.R. (Pa l R.)
Nohr, C. (Christian)
Reichetzeder, C. (Christoph)
Ring, S.M. (Susan)
Ruth, K.S. (Katherine S.)
Santa-Marina, L. (Loreto)
Scholtens, D.M. (Denise M.)
Sebert, S. (Sylvain)
Sengpiel, V. (Verena)
Tuke, M.A. (Marcus A.)
Vaudel, M. (Marc)
Weedon, M.N. (Michael)
Willemsen, G.A.H.M. (Gonneke)
Wood, A.R. (Andrew R.)
Yaghootkar, H. (Hanieh)
Muglia, L.J. (Louis J.)
Bartels, M. (Meike)
Relton, C.L. (Caroline)
Pennell, C.E. (Craig)
Chatzi, L. (Leda)
Estivill, X. (Xavier)
Holloway, J.W. (John W.)
Boomsma, D.I. (Dorret)
Montgomery, G.W. (Grant W.)
Murabito, J. (Joanne)
Spector, T.D. (Timothy)
Power, C. (Christine)
Järvelin, M.-R. (Marjo-Ritta)
Bisgaard, H. (Hans)
Grant, S.F.A. (Struan F.A.)
Sørensen, T.I.A. (Thorkild I.A.)
Jaddoe, V.W. (Vincent W.)
Jacobsson, B. (Bo)
Melbye, M. (Mads)
McCarthy, M.I. (Mark I.)
Hattersley, A.T. (Andrew)
Hayes, M.G. (M. Geoffrey)
Frayling, T.M. (Timothy)
Hivert, M.-F. (Marie-France)
Felix, J.F. (Janine)
Hyppönen, E. (Elina)
Lowe, W.L. (William L.)
Evans, D.M. (David M.)
Lawlor, D.A. (Debbie A.)
Feenstra, B. (Bjarke)
Freathy, R.M. (Rachel)
Publication Year :
2018

Abstract

Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated with birth weight that could highlight potentially relevant maternal determinants of fetal growth. We meta-analysed data on up to 8.7 million SNPs in up to 86 577 women of Eu

Details

Database :
OAIster
Notes :
application/pdf, Human Molecular Genetics vol. 27 no. 4, pp. 742-756, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1042809658
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1093.hmg.ddx429