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Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes
- Publication Year :
- 2017
-
Abstract
- Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) in which cells morphologically resemble abnormal megakaryoblasts. While rare in adults, AMKL accounts for 4–15% of newly diagnosed childhood AML cases. AMKL in individuals without Down syndrome (non-DS-AMKL) is frequently associated with poor clinical outcomes. Previous efforts have identified chimeric oncogenes in a substantial number of
Details
- Database :
- OAIster
- Notes :
- Nature Genetics, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1042808823
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1038.ng.3772