Testosterone, obesity, and waist circumference as determinants of metabolic syndrome in Saudi women

Sameer H Fatani,1 Nazik Altayeb Abdelbasit,1 Hiba S Al-Amodi,1 Maowia Mohamed Mukhtar,2 Abdullatif Taha Babakr1 1Department of Medical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia; 2Department of Molecular Biology, Institute of Endemic Diseases, University of Khartoum, Medical Campus, Khartoum, Sudan Background: High serum total testosterone is associated with metabolic syndrome (MS). This study aimed to identify possible alterations in total testosterone and their relationship with plasma glucose, blood pressure, and serum lipid profile. Methods: One hundred forty-two female subjects were selected to participate in this study, and they were recruited by consultant physicians from the Clinic and Medical Out-Patient, King Abdulaziz Hospital, Kingdom of Saudi Arabia. The anthropometric characteristics were obtained from questionnaires by using standard methods. Blood samples were obtained for the determination of glucose, triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein by using enzymatic methods. Total testosterone was determined by enzyme-linked immunosorbent assay for the quantitative measurement of testosterone in human serum. Results: Significantly higher concentrations of total testosterone, low-density lipoprotein, and glucose, but lower concentrations of high-density lipoprotein, were observed in subjects with MS compared with women without MS (P<0.05). Conclusion: This study suggests that high levels of total testosterone and disturbance in lipid profile were associated with MS in Saudi women. Keywords: obesity, hyperlipidemia, testosterone, metabolic syndrome, lipid profile, androgen, insulin resistanceA Letter to the Editor has been received and published for this article.