4)女性SLE患者における長期ステロイド服用と骨粗鬆症に関する検討(シンポジウム 骨粗鬆症の病態・治療・予防, 第493回新潟医学会)

Osteoporosis is now recognized as one of the major problems of female SLE patients. We measured bone mineral density (BMD) in 54 female SLE patients using dual energy X-ray absorptiometory, and studied the relationship between BMD and clinical parameters or steroid and vitamine D treatment. There was an inverted relation between patient's age and BMD. BMD decreased remarkably in the age of forties and fifties. In the series study of BMD, both patients treated with vitamine D metabolites (group A) and those of untreated (group B) revealed no difference between initial and last BMD, The initial BMD of group A was significantly lower than that of group B. It means that vitamine D methabolites were administrated in patient showing lower DEXA. No remarkable difference were detected in serum biochemical parameters, creatinine clearance and urinary findings between two groups. BMD was not different between both nephrotic and non-nephrotic patients or between those with or without aseptic necrosis of femaral head. Further prospective controlled studies showed be performed to confirm the efficiency of vitamine D metabolites.