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Meta-analysis on the association of VEGFR1 genetic variants with sunitinib outcome in metastatic renal cell carcinoma patients
- Publication Year :
- 2017
-
Abstract
- VEGFR1 rs9582036 and rs9554320 were previously reported the association with sunitinib progression-free survival (PFS) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). Hereafter, the association of both single nucleotide polymorphisms (SNPs) with PFS/OS was confirmed in two independent mRCC cohorts. The aim of the current study was to validate the associations of both SNPs with sunitinib outcome in three independent well-characterized cohorts (SUTOX, CCF and SOGUG) including 286 sunitinib-treated mRCC patients, as well as to perform a meta-analysis of current and published data combined. We found that rs9582036 and rs9554320 showed a significant association with sunitinib PFS in the CCF cohort (HR: 0.254, 95%CI: 0.092-0.703; P=0.008 and HR: 0.430, 95%CI: 0.200- 0.927
Details
- Database :
- OAIster
- Notes :
- application/pdf, Oncotarget vol. 8 no. 1, pp. 1204-1212, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1019672521
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.18632.oncotarget.13597