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Prediction of breast cancer risk based on profiling with common genetic variants
Authors :
Mavaddat, N. (Nasim) Pharoah, P.D.P. (Paul) Michailidou, K. (Kyriaki) Tyrer, J.P. (Jonathan) Brook, M.N. (Mark N.) Bolla, M.K. (Manjeet) Wang, Q. (Qing) Dennis, J. (Joe) Dunning, A.M. (Alison) Shah, M. (Mitul) Luben, R.N. (Robert) Brown, J. (Judith) Bojesen, S.E. (Stig) Nordestgaard, B.G. (Børge) Nielsen, S.F. (Sune F.) Flyger, H. (Henrik) Czene, K. (Kamila) Darabi, H. (Hatef) Eriksson, M. (Mikael) Peto, J. (Julian) Santos Silva, I. (Isabel) dos Dudbridge, F. (Frank) Johnson, N. (Nichola) Schmidt, M.K. (Marjanka) Broeks, A. (Annegien) Verhoef, S. Rutgers, E.J. (Emiel J.) Swerdlow, A.J. (Anthony ) Ashworth, A. (Alan) Orr, N. (Nick) Schoemaker, M. (Minouk) Figueroa, J.D. (Jonine) Chanock, S.J. (Stephen) Brinton, L.A. (Louise) Lissowska, J. (Jolanta) Couch, F.J. (Fergus) Olson, J.E. (Janet) Vachon, C. (Celine) Pankratz, V.S. (Shane) Lambrechts, D. (Diether) Wildiers, H. (Hans) van Ongeval, C. (Chantal) Limbergen, E. (Erik) van Kristensen, V. (Vessela) Grenaker Alnæs, G. (Grethe) Nord, S. (Silje) Borresen-Dale, A.-L. (Anne-Lise) Nevanlinna, H. (Heli) Muranen, T.A. (Taru) Aittomäki, K. (Kristiina) Blomqvist, C. (Carl) Chang-Claude, J. (Jenny) Rudolph, A. (Anja) Seibold, P. (Petra) Flesch-Janys, D. (Dieter) Fasching, P.A. (Peter) Haeberle, L. (Lothar) Ekici, A.B. (Arif) Beckmann, M.W. (Matthias) Burwinkel, B. (Barbara) Marme, F. (Federick) Schneeweiss, A. (Andreas) Sohn, C. (Christof) Trentham-Dietz, A. (Amy) Newcomb, P. (Polly) Titus, L. (Linda) Egan, K.M. (Kathleen M.) Hunter, D. (David) Lindstrom, S. (Stephen) Tamimi, R. (Rulla) Kraft, P. (Peter) Rahman, N. (Nazneen) Turnbull, C. (Clare) Renwick, A. (Anthony) Seal, S. (Sheila) Li, J. (Jingmei) Liu, J. (Jianjun) Humphreys, M.K. (Manjeet) Benítez, J. (Javier) Zamora, M.P. (Pilar) Arias Pérez, J.I. (José Ignacio) Menéndez, P. (Primitiva) Jakubowska, A. (Anna) Lubinski, J. (Jan) Jaworska-Bieniek, K. (Katarzyna) Durda, K. (Katarzyna) Bogdanova, N.V. (Natalia) Antonenkova, N.N. (Natalia) Dörk, T. (Thilo) Anton-Culver, H. (Hoda) Neuhausen, S.L. (Susan) Ziogas, A. (Argyrios) Bernstein, L. (Leslie) Devilee, P. (Peter) Tollenaar, R.A.E.M. (Rob) Seynaeve, C.M. (Caroline) Asperen, C.J. (Christi) van Cox, A. (Angela) Cross, S.S. (Simon) Reed, M.W.R. (Malcolm) Khusnutdinova, E.K. (Elza) Bermisheva, M. (Marina) Prokofyeva, D. (Darya) Takhirova, Z. (Zalina) Meindl, A. (Alfons) Schmutzler, R.K. (Rita) Sutter, C. (Christian) Yang, R. (Rongxi) Schürmann, P. (Peter) Bremer, M. (Michael) Christiansen, H. (Hans) Park-Simon, T.-W. Hillemanns, P. (Peter) Guénel, P. (Pascal) Truong, T. (Thérèse) Menegaux, F. (Florence) Sanchez, M. (Marie) Radice, P. (Paolo) Peterlongo, P. (Paolo) Manoukian, S. (Siranoush) Pensotti, V. (Valeria) Hopper, J. (John) Tsimiklis, H. (Helen) Apicella, C. (Carmel) Southey, M.C. (Melissa) Brauch, H. (Hiltrud) Brüning, T. (Thomas) Ko, Y.-D. (Yon-Dschun) Sigurdson, A.J. (Alice) Doody, M.M. (Michele M.) Hamann, U. (Ute) Torres, D. (Diana) Ulmer, H.U. (Hans) Försti, A. (Asta) Sawyer, E.J. (Elinor) Tomlinson, I.P. (Ian) Kerin, M. (Michael) Miller, N. (Nicola) Andrulis, I.L. (Irene) Knight, J.A. (Julia) Glendon, G. (Gord) Mulligan, A.M. (Anna Marie) Chenevix-Trench, G. (Georgia) Balleine, R. (Rosemary) Giles, G.G. (Graham) Milne, R.L. (Roger) McLean, C.A. (Catriona Ann) Lindblom, A. (Annika) Margolin, S. (Sara) Haiman, C.A. (Christopher) Henderson, B.E. (Brian) Schumacher, F. (Fredrick) Le Marchand, L. (Loic) Eilber, U. (Ursula) Wang-Gohrke, S. (Shan) Hooning, M.J. (Maartje) Hollestelle, A. (Antoinette) Ouweland, A.M.W. (Ans) van den Koppert, L.B. (Linetta) Carpenter, J. (Jane) Clarke, C. (Christine) Scott, R.J. (Rodney J.) Mannermaa, A. (Arto) Kataja, V. (Vesa) Kosma, V-M. (Veli-Matti) Hartikainen, J.M. (J.) Brenner, H. (Hermann) Arndt, V. (Volker) Stegmaier, C. (Christa) Karina Dieffenbach, A. (Aida) Winqvist, R. (Robert) Pykäs, K. (Katri) Jukkola-Vuorinen, A. (Arja) Grip, M. (Mervi) Offit, K. (Kenneth) Vijai, J. (Joseph) Robson, M. (Mark) Rau-Murthy, R. (Rohini) Dwek, M. (Miriam) Swann, R. (Ruth) Perkins, K.A. (Katherine) Goldberg, M.S. (Mark) Labrèche, F. (France) Dumont, M. (Martine) Eccles, D. (Diana) Tapper, W. (William) Rafiq, M. (Meena) John, E.M. (Esther M.) Whittemore, A.S. (Alice) Slager, S. (Susan) Yannoukakos, D. (Drakoulis) Toland, A.E. (Amanda) Yao, S. (Song) Zheng, W. (Wei) Halverson, S.L. (Sandra L.) González-Neira, A. (Anna) Pita, G. (Guillermo) Rosario Alonso, M. Álvarez, N. (Nuria) Herrero, D. (Daniel) Tessier, D.C. (Daniel C.) Vincent, D. (Daniel) Bacot, F. (Francois) Luccarini, C. (Craig) Baynes, C. (Caroline) Ahmed, S. (Shahana) Maranian, M. (Melanie) Healey, S. (Sue) Simard, J. (Jacques) Hall, P. (Per) Easton, D.F. (Douglas) García-Closas, M. (Montserrat) Mavaddat, N. (Nasim) Pharoah, P.D.P. (Paul) Michailidou, K. (Kyriaki) Tyrer, J.P. (Jonathan) Brook, M.N. (Mark N.) Bolla, M.K. (Manjeet) Wang, Q. (Qing) Dennis, J. (Joe) Dunning, A.M. (Alison) Shah, M. (Mitul) Luben, R.N. (Robert) Brown, J. (Judith) Bojesen, S.E. (Stig) Nordestgaard, B.G. (Børge) Nielsen, S.F. (Sune F.) Flyger, H. (Henrik) Czene, K. (Kamila) Darabi, H. (Hatef) Eriksson, M. (Mikael) Peto, J. (Julian) Santos Silva, I. (Isabel) dos Dudbridge, F. (Frank) Johnson, N. (Nichola) Schmidt, M.K. (Marjanka) Broeks, A. (Annegien) Verhoef, S. Rutgers, E.J. (Emiel J.) Swerdlow, A.J. (Anthony ) Ashworth, A. (Alan) Orr, N. (Nick) Schoemaker, M. (Minouk) Figueroa, J.D. (Jonine) Chanock, S.J. (Stephen) Brinton, L.A. (Louise) Lissowska, J. (Jolanta) Couch, F.J. (Fergus) Olson, J.E. (Janet) Vachon, C. (Celine) Pankratz, V.S. (Shane) Lambrechts, D. (Diether) Wildiers, H. (Hans) van Ongeval, C. (Chantal) Limbergen, E. (Erik) van Kristensen, V. (Vessela) Grenaker Alnæs, G. (Grethe) Nord, S. (Silje) Borresen-Dale, A.-L. (Anne-Lise) Nevanlinna, H. (Heli) Muranen, T.A. (Taru) Aittomäki, K. (Kristiina) Blomqvist, C. (Carl) Chang-Claude, J. (Jenny) Rudolph, A. (Anja) Seibold, P. (Petra) Flesch-Janys, D. (Dieter) Fasching, P.A. (Peter) Haeberle, L. (Lothar) Ekici, A.B. (Arif) Beckmann, M.W. (Matthias) Burwinkel, B. (Barbara) Marme, F. (Federick) Schneeweiss, A. (Andreas) Sohn, C. (Christof) Trentham-Dietz, A. (Amy) Newcomb, P. (Polly) Titus, L. (Linda) Egan, K.M. (Kathleen M.) Hunter, D. (David) Lindstrom, S. (Stephen) Tamimi, R. (Rulla) Kraft, P. (Peter) Rahman, N. (Nazneen) Turnbull, C. (Clare) Renwick, A. (Anthony) Seal, S. (Sheila) Li, J. (Jingmei) Liu, J. (Jianjun) Humphreys, M.K. (Manjeet) Benítez, J. (Javier) Zamora, M.P. (Pilar) Arias Pérez, J.I. (José Ignacio) Menéndez, P. (Primitiva) Jakubowska, A. (Anna) Lubinski, J. (Jan) Jaworska-Bieniek, K. (Katarzyna) Durda, K. (Katarzyna) Bogdanova, N.V. (Natalia) Antonenkova, N.N. (Natalia) Dörk, T. (Thilo) Anton-Culver, H. (Hoda) Neuhausen, S.L. (Susan) Ziogas, A. (Argyrios) Bernstein, L. (Leslie) Devilee, P. (Peter) Tollenaar, R.A.E.M. (Rob) Seynaeve, C.M. (Caroline) Asperen, C.J. (Christi) van Cox, A. (Angela) Cross, S.S. (Simon) Reed, M.W.R. (Malcolm) Khusnutdinova, E.K. (Elza) Bermisheva, M. (Marina) Prokofyeva, D. (Darya) Takhirova, Z. (Zalina) Meindl, A. (Alfons) Schmutzler, R.K. (Rita) Sutter, C. (Christian) Yang, R. (Rongxi) Schürmann, P. (Peter) Bremer, M. (Michael) Christiansen, H. (Hans) Park-Simon, T.-W. Hillemanns, P. (Peter) Guénel, P. (Pascal) Truong, T. (Thérèse) Menegaux, F. (Florence) Sanchez, M. (Marie) Radice, P. (Paolo) Peterlongo, P. (Paolo) Manoukian, S. (Siranoush) Pensotti, V. (Valeria) Hopper, J. (John) Tsimiklis, H. (Helen) Apicella, C. (Carmel) Southey, M.C. (Melissa) Brauch, H. (Hiltrud) Brüning, T. (Thomas) Ko, Y.-D. (Yon-Dschun) Sigurdson, A.J. (Alice) Doody, M.M. (Michele M.) Hamann, U. (Ute) Torres, D. (Diana) Ulmer, H.U. (Hans) Försti, A. (Asta) Sawyer, E.J. (Elinor) Tomlinson, I.P. (Ian) Kerin, M. (Michael) Miller, N. (Nicola) Andrulis, I.L. (Irene) Knight, J.A. (Julia) Glendon, G. (Gord) Mulligan, A.M. (Anna Marie) Chenevix-Trench, G. (Georgia) Balleine, R. (Rosemary) Giles, G.G. (Graham) Milne, R.L. (Roger) McLean, C.A. (Catriona Ann) Lindblom, A. (Annika) Margolin, S. (Sara) Haiman, C.A. (Christopher) Henderson, B.E. (Brian) Schumacher, F. (Fredrick) Le Marchand, L. (Loic) Eilber, U. (Ursula) Wang-Gohrke, S. (Shan) Hooning, M.J. (Maartje) Hollestelle, A. (Antoinette) Ouweland, A.M.W. (Ans) van den Koppert, L.B. (Linetta) Carpenter, J. (Jane) Clarke, C. (Christine) Scott, R.J. (Rodney J.) Mannermaa, A. (Arto) Kataja, V. (Vesa) Kosma, V-M. (Veli-Matti) Hartikainen, J.M. (J.) Brenner, H. (Hermann) Arndt, V. (Volker) Stegmaier, C. (Christa) Karina Dieffenbach, A. (Aida) Winqvist, R. (Robert) Pykäs, K. (Katri) Jukkola-Vuorinen, A. (Arja) Grip, M. (Mervi) Offit, K. (Kenneth) Vijai, J. (Joseph) Robson, M. (Mark) Rau-Murthy, R. (Rohini) Dwek, M. (Miriam) Swann, R. (Ruth) Perkins, K.A. (Katherine) Goldberg, M.S. (Mark) Labrèche, F. (France) Dumont, M. (Martine) Eccles, D. (Diana) Tapper, W. (William) Rafiq, M. (Meena) John, E.M. (Esther M.) Whittemore, A.S. (Alice) Slager, S. (Susan) Yannoukakos, D. (Drakoulis) Toland, A.E. (Amanda) Yao, S. (Song) Zheng, W. (Wei) Halverson, S.L. (Sandra L.) González-Neira, A. (Anna) Pita, G. (Guillermo) Rosario Alonso, M. Álvarez, N. (Nuria) Herrero, D. (Daniel) Tessier, D.C. (Daniel C.) Vincent, D. (Daniel) Bacot, F. (Francois) Luccarini, C. (Craig) Baynes, C. (Caroline) Ahmed, S. (Shahana) Maranian, M. (Melanie) Healey, S. (Sue) Simard, J. (Jacques) Hall, P. (Per) Easton, D.F. (Douglas) García-Closas, M. (Montserrat)
Publication Year :
2015
Abstract
Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and construc
Details
Database :
OAIster
Notes :
application/pdf, National Cancer Institute. Journal (Print) vol. 107 no. 5, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn957103486
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1093.jnci.djv036