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Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer
Authors :
Kabisch, M. (Maria) Bermejo, J.L. (Justo Lorenzo) Dünnebier, T. (Thomas) Ying, S. (Shibo) Michailidou, K. (Kyriaki) Bolla, M.K. (Manjeet) Wang, Q. (Qing) Dennis, J. (Joe) Shah, M. (Mitul) Perkins, B. (Barbara) Czene, K. (Kamila) Darabi, H. (Hatef) Eriksson, M. (Mikael) Bojesen, S.E. (Stig) Nordestgaard, B.G. (Børge) Nielsen, S.F. (Sune) Flyger, H. (Henrik) Lambrechts, D. (Diether) Neven, P. (Patrick) Peeters, S.T.H. (Stephanie) Weltens, C. (Caroline) Couch, F.J. (Fergus) Olson, J.E. (Janet) Wang, X. (Xianshu) Purrington, K. (Kristen) Chang-Claude, J. (Jenny) Rudolph, A. (Anja) Seibold, P. (Petra) Flesch-Janys, D. (Dieter) Peto, J. (Julian) Santos Silva, I. (Isabel) dos Johnson, N. (Nichola) Fletcher, O. (Olivia) Nevanlinna, H. (Heli) Muranen, T.A. (Taru) Aittomäki, K. (Kristiina) Blomqvist, C. (Carl) Schmidt, M.K. (Marjanka) Broeks, A. (Annegien) Cornelissen, S. (Sten) Hogervorst, F.B.L. (Frans) Li, J. (Jingmei) Brand, J.S. (Judith S.) Humphreys, M.K. (Manjeet) Guénel, P. (Pascal) Truong, T. (Thérèse) Menegaux, F. (Florence) Sanchez, M. (Marie) Burwinkel, B. (Barbara) Marme, F. (Federick) Yang, R. (Rongxi) Bugert, P. (Peter) González-Neira, A. (Anna) Benítez, J. (Javier) Zamora, M.P. (Pilar) Arias Pérez, J.I. (José Ignacio) Cox, A. (Angela) Cross, S.S. (Simon) Reed, M.W.R. (Malcolm) Andrulis, I.L. (Irene) Knight, J.A. (Julia) Glendon, G. (Gord) Tchatchou, S. (Sandrine) Sawyer, E.J. (Elinor) Tomlinson, I.P. (Ian) Kerin, M. (Michael) Miller, N. (Nicola) Haiman, C.A. (Christopher) Schumacher, F.R. (Fredrick) Henderson, B.E. (Brian) Le Marchand, L. (Loic) Lindblom, A. (Annika) Margolin, S. (Sara) Hooning, M.J. (Maartje) Hollestelle, A. (Antoinette) Kriege, M. (Mieke) Koppert, L.B. (Linetta) Hopper, J. (John) Southey, M.C. (Melissa) Tsimiklis, H. (Helen) Apicella, C. (Carmel) Slettedahl, S. (Seth) Toland, A.E. (Amanda) Vachon, C. (Celine) Yannoukakos, D. (Drakoulis) Giles, G.G. (Graham) Milne, R.L. (Roger) McLean, C.A. (Catriona Ann) Fasching, P.A. (Peter) Ruebner, M. (Matthias) Ekici, A.B. (Arif) Beckmann, M.W. (Matthias) Brenner, H. (Hermann) Dieffenbach, A.K. (Aida Karina) Arndt, V. (Volker) Stegmaier, C. (Christa) Ashworth, A. (Alan) Orr, N. (Nick) Schoemaker, M. (Minouk) Swerdlow, A.J. (Anthony ) García-Closas, M. (Montserrat) Figueroa, J.D. (Jonine) Chanock, S.J. (Stephen) Lissowska, J. (Jolanta) Goldberg, M.S. (Mark) Labrèche, F. (France) Dumont, M. (Martine) Winqvist, R. (Robert) Pykäs, K. (Katri) Jukkola-Vuorinen, A. (Arja) Grip, M. (Mervi) Brauch, H. (Hiltrud) Brüning, T. (Thomas) Ko, Y-D. (Yon-Dschun) Radice, P. (Paolo) Peterlongo, P. (Paolo) Scuvera, G. (Giulietta) Fortuzzi, S. (S.) Bogdanova, N.V. (Natalia) Dörk, T. (Thilo) Mannermaa, A. (Arto) Kataja, V. (Vesa) Kosma, V-M. (Veli-Matti) Hartikainen, J.M. (J.) Devilee, P. (Peter) Tollenaar, R.A.M. (Robert A.M.) Seynaeve, C.M. (Caroline) Asperen, C.J. (Christi) van Jakubowska, A. (Anna) Lubinski, J. (Jan) Jaworska-Bieniek, K. (Katarzyna) Durda, K. (Katarzyna) Zheng, W. (Wei) Shrubsole, M. (Martha) Cai, Q. (Qiuyin) Torres, D. (Diana) Anton-Culver, H. (Hoda) Kristensen, V. (Vessela) Bacot, F. (Francois) Tessier, D.C. (Daniel C.) Vincent, D. (Daniel) Luccarini, C. (Craig) Baynes, C. (Caroline) Ahmed, S. (Shahana) Maranian, M. (Melanie) Simard, J. (Jacques) Chenevix-Trench, G. (Georgia) Hall, P. (Per) Pharoah, P.D.P. (Paul) Dunning, A.M. (Alison) Easton, D.F. (Douglas) Hamann, U. (Ute) Kabisch, M. (Maria) Bermejo, J.L. (Justo Lorenzo) Dünnebier, T. (Thomas) Ying, S. (Shibo) Michailidou, K. (Kyriaki) Bolla, M.K. (Manjeet) Wang, Q. (Qing) Dennis, J. (Joe) Shah, M. (Mitul) Perkins, B. (Barbara) Czene, K. (Kamila) Darabi, H. (Hatef) Eriksson, M. (Mikael) Bojesen, S.E. (Stig) Nordestgaard, B.G. (Børge) Nielsen, S.F. (Sune) Flyger, H. (Henrik) Lambrechts, D. (Diether) Neven, P. (Patrick) Peeters, S.T.H. (Stephanie) Weltens, C. (Caroline) Couch, F.J. (Fergus) Olson, J.E. (Janet) Wang, X. (Xianshu) Purrington, K. (Kristen) Chang-Claude, J. (Jenny) Rudolph, A. (Anja) Seibold, P. (Petra) Flesch-Janys, D. (Dieter) Peto, J. (Julian) Santos Silva, I. (Isabel) dos Johnson, N. (Nichola) Fletcher, O. (Olivia) Nevanlinna, H. (Heli) Muranen, T.A. (Taru) Aittomäki, K. (Kristiina) Blomqvist, C. (Carl) Schmidt, M.K. (Marjanka) Broeks, A. (Annegien) Cornelissen, S. (Sten) Hogervorst, F.B.L. (Frans) Li, J. (Jingmei) Brand, J.S. (Judith S.) Humphreys, M.K. (Manjeet) Guénel, P. (Pascal) Truong, T. (Thérèse) Menegaux, F. (Florence) Sanchez, M. (Marie) Burwinkel, B. (Barbara) Marme, F. (Federick) Yang, R. (Rongxi) Bugert, P. (Peter) González-Neira, A. (Anna) Benítez, J. (Javier) Zamora, M.P. (Pilar) Arias Pérez, J.I. (José Ignacio) Cox, A. (Angela) Cross, S.S. (Simon) Reed, M.W.R. (Malcolm) Andrulis, I.L. (Irene) Knight, J.A. (Julia) Glendon, G. (Gord) Tchatchou, S. (Sandrine) Sawyer, E.J. (Elinor) Tomlinson, I.P. (Ian) Kerin, M. (Michael) Miller, N. (Nicola) Haiman, C.A. (Christopher) Schumacher, F.R. (Fredrick) Henderson, B.E. (Brian) Le Marchand, L. (Loic) Lindblom, A. (Annika) Margolin, S. (Sara) Hooning, M.J. (Maartje) Hollestelle, A. (Antoinette) Kriege, M. (Mieke) Koppert, L.B. (Linetta) Hopper, J. (John) Southey, M.C. (Melissa) Tsimiklis, H. (Helen) Apicella, C. (Carmel) Slettedahl, S. (Seth) Toland, A.E. (Amanda) Vachon, C. (Celine) Yannoukakos, D. (Drakoulis) Giles, G.G. (Graham) Milne, R.L. (Roger) McLean, C.A. (Catriona Ann) Fasching, P.A. (Peter) Ruebner, M. (Matthias) Ekici, A.B. (Arif) Beckmann, M.W. (Matthias) Brenner, H. (Hermann) Dieffenbach, A.K. (Aida Karina) Arndt, V. (Volker) Stegmaier, C. (Christa) Ashworth, A. (Alan) Orr, N. (Nick) Schoemaker, M. (Minouk) Swerdlow, A.J. (Anthony ) García-Closas, M. (Montserrat) Figueroa, J.D. (Jonine) Chanock, S.J. (Stephen) Lissowska, J. (Jolanta) Goldberg, M.S. (Mark) Labrèche, F. (France) Dumont, M. (Martine) Winqvist, R. (Robert) Pykäs, K. (Katri) Jukkola-Vuorinen, A. (Arja) Grip, M. (Mervi) Brauch, H. (Hiltrud) Brüning, T. (Thomas) Ko, Y-D. (Yon-Dschun) Radice, P. (Paolo) Peterlongo, P. (Paolo) Scuvera, G. (Giulietta) Fortuzzi, S. (S.) Bogdanova, N.V. (Natalia) Dörk, T. (Thilo) Mannermaa, A. (Arto) Kataja, V. (Vesa) Kosma, V-M. (Veli-Matti) Hartikainen, J.M. (J.) Devilee, P. (Peter) Tollenaar, R.A.M. (Robert A.M.) Seynaeve, C.M. (Caroline) Asperen, C.J. (Christi) van Jakubowska, A. (Anna) Lubinski, J. (Jan) Jaworska-Bieniek, K. (Katarzyna) Durda, K. (Katarzyna) Zheng, W. (Wei) Shrubsole, M. (Martha) Cai, Q. (Qiuyin) Torres, D. (Diana) Anton-Culver, H. (Hoda) Kristensen, V. (Vessela) Bacot, F. (Francois) Tessier, D.C. (Daniel C.) Vincent, D. (Daniel) Luccarini, C. (Craig) Baynes, C. (Caroline) Ahmed, S. (Shahana) Maranian, M. (Melanie) Simard, J. (Jacques) Chenevix-Trench, G. (Georgia) Hall, P. (Per) Pharoah, P.D.P. (Paul) Dunning, A.M. (Alison) Easton, D.F. (Douglas) Hamann, U. (Ute)
Publication Year :
2014
Abstract
The chromosomal passenger complex (CPC) plays a pivotal role in the regulation of cell division. Therefore, inherited CPC variability could influence tumor development. The present candidate gene approach investigates the relationship between single nucleotide polymorphisms (SNPs) in genes encoding key CPC components and breast cancer risk. Fifteen SNPs in four CPC genes (INCENP, AURKB, BIRC5 and CDCA8) were genotyped in 88 911 European women from 39 case-control studies of the Breast Cancer Association Consortium. Possible associations were investigated in fixedeffects meta-analyses. The synonymous SNP rs1675126 in exon 7 of INCENP was associated with overall breast cancer risk [per A allele odds ratio (OR) 0.95, 95% confidence interval (CI) 0.92-0.98, P = 0.007] and particularly with estrogen receptor (ER)-negative breast tumors (per A allele OR 0.89, 95% CI 0.83-0.95, P = 0.0005). SNPs not directly genotyped were imputed based on 1000 Genomes. The SNPs rs1047739 in the 3′ untranslated region and rs144045115 downstream of INCENP showed the strongest association signals for overall (per T allele OR 1.03, 95% CI 1.00-1.06, P = 0.0009) and ER-negative breast cancer risk (per A allele OR 1.06, 95% CI 1.02-1.10, P = 0.0002). Two genotyped SNPs in BIRC5 were associated with familial breast cancer risk (top SNP rs2071214: per G allele OR 1.12, 95% CI 1.04-1.21, P = 0.002). The data suggest that INCENP in the CPC pathway contributes to ER-nega
Details
Database :
OAIster
Notes :
Carcinogenesis: integrative cancer research vol. 36 no. 2, pp. 256-271, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn957101870
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1093.carcin.bgu326