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Rheb is essential for murine development
- Publication Year :
- 2011
-
Abstract
- Ras homolog enriched in brain (Rheb) couples growth factor signaling to activation of the target of rapamycin complex 1 (TORC1). To study its role in mammals, we generated a Rheb knockout mouse. In contrast to mTOR or regulatory-associated protein of mTOR (Raptor) mutants, the inner cell mass of Rheb-/-embryos differentiated normally. Nevertheless, Rheb-/-embryos died around midgestation, most likely due to impaired development of the cardiovascular system. Rheb-/-embryonic fibroblasts showed decreased TORC1 activity, were smaller, and showed impaired proliferation. Rheb heterozygosity extended the life span of tuberous sclerosis complex 1-deficient (Tsc1-/-) embryos, indicating that there is a genetic interaction between the Tsc1 and Rheb genes in mouse.
Details
- Database :
- OAIster
- Notes :
- Molecular and Cellular Biology vol. 31 no. 8, pp. 1672-1678, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn957100193
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1128.MCB.00985-10