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Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Authors :
Leeuwen, E.M. (Elisa) van
Sabo, A. (Aniko)
Bis, J.C. (Joshua)
Huffman, J.E. (Jennifer)
Manichaikul, A. (Ani)
Smith, A.V. (Davey)
Feitosa, M.F. (Mary Furlan)
Demissie, S. (Serkalem)
Joshi, P.K. (Peter)
Duan, Q. (Qing)
Marten, J. (Jonathan)
Klinken, J.B. (Jan Bert) van
Surakka, I. (Ida)
Nolte, I.M. (Ilja)
Zhang, W. (Weihua)
Mbarek, H.
Li-Gao, R. (Ruifang)
Trompet, S. (Stella)
Verweij, N. (Niek)
Evangelou, E. (Evangelos)
Lyytikäinen, L.-P. (Leo-Pekka)
Tayo, B. (Bamidele)
Deelen, J. (Joris)
Most, P.J. (Peter) van der
Van Der Laan, S.W. (Sander W.)
Arking, D.E. (Dan E.)
Morrison, A. (Alanna)
Dehghan, A. (Abbas)
Franco, O.H. (Oscar)
Hofman, A. (Albert)
Rivadeneira Ramirez, F. (Fernando)
Sijbrands, E.J.G. (Eric)
Uitterlinden, A.G. (André)
Mychaleckyj, J.C. (Josyf)
Campbell, A. (Archie)
Hocking, L.J. (Lynne)
Padmanabhan, S. (Sandosh)
Brody, J.A. (Jennifer A.)
Rice, K.M. (Kenneth)
White, C.C. (Charles)
Harris, T.B. (Tamara)
Isaacs, A.J. (Aaron)
Campbell, H. (Harry)
Lange, L.A. (Leslie)
Rudan, I. (Igor)
Kolcic, I. (Ivana)
Navarro, P. (Pau)
Zemunik, T. (Tatijana)
Salomaa, V. (Veikko)
Kooner, J.S. (Jaspal)
Kooner, J.S. (Jaspal S.)
Lehne, B. (Benjamin)
Scott, W.R. (William R.)
Tan, S.-T. (Sian-Tsung)
Geus, E.J.C. (Eco) de
Milaneschi, Y. (Yuri)
Penninx, B.W.J.H. (Brenda)
Willemsen, G.A.H.M. (Gonneke)
Mutsert, R. (Reneé) de
Ford, I. (Ian)
Gansevoort, R.T. (Ron)
Segura-Lepe, M.P. (Marcelo P.)
Raitakari, O.T. (Olli T.)
Viikari, J. (Jorma)
Nikus, K. (Kjell)
Forrester, T. (Terrence)
McKenzie, C.A. (Colin)
Craen, A.J. (Anton) de
de Ruijter, H.M. (Hester M.)
Pasterkamp, G. (Gerard)
Snieder, H. (Harold)
Oldehinkel, A.J. (Albertine)
Slagboom, P.E. (Eline)
Cooper, R.S. (Richard S.)
Kähönen, M. (Mika)
Lehtimäki, T. (Terho)
Elliott, P. (Paul)
Harst, P. (Pim) van der
Jukema, J.W. (Jan Wouter)
Mook-Kanamori, D.O. (Dennis)
Boomsma, D.I. (Dorret)
Chambers, J.C. (John C.)
Swertz, M. (Morris)
Ripatti, S. (Samuli)
Willems van Dijk, J.A.P. (Ko)
Vitart, V. (Veronique)
Polasek, O. (Ozren)
Hayward, C. (Caroline)
Wilson, J.G. (James G.)
Wilson, J.F. (James F)
Gudnason, V. (Vilmundur)
Rich, S.S. (Stephen)
Psaty, B.M. (Bruce)
Borecki, I.B. (Ingrid)
Boerwinkle, E. (Eric)
Rotter, J.I. (Jerome I.)
Cupples, L.A. (Adrienne)
Duijn, C.M. (Cornelia) van
Leeuwen, E.M. (Elisa) van
Sabo, A. (Aniko)
Bis, J.C. (Joshua)
Huffman, J.E. (Jennifer)
Manichaikul, A. (Ani)
Smith, A.V. (Davey)
Feitosa, M.F. (Mary Furlan)
Demissie, S. (Serkalem)
Joshi, P.K. (Peter)
Duan, Q. (Qing)
Marten, J. (Jonathan)
Klinken, J.B. (Jan Bert) van
Surakka, I. (Ida)
Nolte, I.M. (Ilja)
Zhang, W. (Weihua)
Mbarek, H.
Li-Gao, R. (Ruifang)
Trompet, S. (Stella)
Verweij, N. (Niek)
Evangelou, E. (Evangelos)
Lyytikäinen, L.-P. (Leo-Pekka)
Tayo, B. (Bamidele)
Deelen, J. (Joris)
Most, P.J. (Peter) van der
Van Der Laan, S.W. (Sander W.)
Arking, D.E. (Dan E.)
Morrison, A. (Alanna)
Dehghan, A. (Abbas)
Franco, O.H. (Oscar)
Hofman, A. (Albert)
Rivadeneira Ramirez, F. (Fernando)
Sijbrands, E.J.G. (Eric)
Uitterlinden, A.G. (André)
Mychaleckyj, J.C. (Josyf)
Campbell, A. (Archie)
Hocking, L.J. (Lynne)
Padmanabhan, S. (Sandosh)
Brody, J.A. (Jennifer A.)
Rice, K.M. (Kenneth)
White, C.C. (Charles)
Harris, T.B. (Tamara)
Isaacs, A.J. (Aaron)
Campbell, H. (Harry)
Lange, L.A. (Leslie)
Rudan, I. (Igor)
Kolcic, I. (Ivana)
Navarro, P. (Pau)
Zemunik, T. (Tatijana)
Salomaa, V. (Veikko)
Kooner, J.S. (Jaspal)
Kooner, J.S. (Jaspal S.)
Lehne, B. (Benjamin)
Scott, W.R. (William R.)
Tan, S.-T. (Sian-Tsung)
Geus, E.J.C. (Eco) de
Milaneschi, Y. (Yuri)
Penninx, B.W.J.H. (Brenda)
Willemsen, G.A.H.M. (Gonneke)
Mutsert, R. (Reneé) de
Ford, I. (Ian)
Gansevoort, R.T. (Ron)
Segura-Lepe, M.P. (Marcelo P.)
Raitakari, O.T. (Olli T.)
Viikari, J. (Jorma)
Nikus, K. (Kjell)
Forrester, T. (Terrence)
McKenzie, C.A. (Colin)
Craen, A.J. (Anton) de
de Ruijter, H.M. (Hester M.)
Pasterkamp, G. (Gerard)
Snieder, H. (Harold)
Oldehinkel, A.J. (Albertine)
Slagboom, P.E. (Eline)
Cooper, R.S. (Richard S.)
Kähönen, M. (Mika)
Lehtimäki, T. (Terho)
Elliott, P. (Paul)
Harst, P. (Pim) van der
Jukema, J.W. (Jan Wouter)
Mook-Kanamori, D.O. (Dennis)
Boomsma, D.I. (Dorret)
Chambers, J.C. (John C.)
Swertz, M. (Morris)
Ripatti, S. (Samuli)
Willems van Dijk, J.A.P. (Ko)
Vitart, V. (Veronique)
Polasek, O. (Ozren)
Hayward, C. (Caroline)
Wilson, J.G. (James G.)
Wilson, J.F. (James F)
Gudnason, V. (Vilmundur)
Rich, S.S. (Stephen)
Psaty, B.M. (Bruce)
Borecki, I.B. (Ingrid)
Boerwinkle, E. (Eric)
Rotter, J.I. (Jerome I.)
Cupples, L.A. (Adrienne)
Duijn, C.M. (Cornelia) van
Publication Year :
2016

Abstract

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resul

Details

Database :
OAIster
Notes :
application/pdf, Journal of Medical Genetics, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn957097643
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1136.jmedgenet-2015-103439
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