RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response

Authors :: Burger, H. (Herman)
Foekens, J.A. (John)
Look, M.P. (Maxime)
Meijer van Gelder, M.E. (Marion)
Klijn, J.G.M. (Jan)
Wiemer, E.A.C. (Erik)
Stoter, G. (Gerrit)
Nooter, K. (Kees)
Burger, H. (Herman)
Foekens, J.A. (John)
Look, M.P. (Maxime)
Meijer van Gelder, M.E. (Marion)
Klijn, J.G.M. (Jan)
Wiemer, E.A.C. (Erik)
Stoter, G. (Gerrit)
Nooter, K. (Kees)
Publication Year :: 2003
Abstract: PURPOSE: The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease. EXPERIMENTAL DESIGN: We determined mRNA levels of BCRP, LRP, MRP1, MRP2, and MDR1 in 59 primary breast tumor specimens of patients who r

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