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Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends
- Publication Year :
- 2005
-
Abstract
- Homologous recombination (HR) requires nuclease activities at multiple steps, but the contribution of individual nucleases to the processing of double-strand DNA ends at different stages of HR has not been clearly defined. We used chicken DT40 cells to investigate the role of flap endonuclease 1 (Fen-1) in HR. FEN-1-deficient cells exhibited a significant decrease in the efficiency of immun
Details
- Database :
- OAIster
- Notes :
- application/pdf, Molecular and Cellular Biology vol. 25 no. 16, pp. 6948-6955, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn929972976
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1128.MCB.25.16.6948-6955.2005