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WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk

Authors :
Zheng, H.-F. (Hou-Feng)
Tobias, J.H. (Jon)
Duncan, E.L. (Emma)
Evans, D.M. (David)
Eriksson, J. (Joel)
Paternoster, L. (Lavinia)
Yerges-Armstrong, L.M. (Laura)
Lehtimäki, T. (Terho)
Bergström, U. (Ulrica)
Kähönen, M. (Mika)
Leo, P.J. (Paul)
Raitakari, O. (Olli)
Laaksonen, M. (Marika)
Nicholson, G.C. (Geoffrey)
Viikari, J. (Jorma)
Ladouceur, M. (Martin)
Lyytikäinen, L.-P. (Leo-Pekka)
Medina-Gomez, M.C. (Carolina)
Rivadeneira Ramirez, F. (Fernando)
Prince, R.L. (Richard)
Sievanen, H. (Harri)
Leslie, W.D. (William)
Mellström, D. (Dan)
Eisman, J.A. (John)
Movérare-Skrtic, S. (Sofia)
Goltzman, D. (David)
Hanley, G.E. (Gillian)
Jones, G. (Graeme)
St Pourcain, B. (Beate)
Xiao, Y. (Yanling)
Timpson, N.J. (Nicholas)
Smith, A.V. (Davey)
Reid, I.R. (Ian)
Ring, S.M. (Susan)
Sambrook, P.N. (Philip)
Karlsson, M. (Magnus)
Dennison, E.M. (Elaine)
Kemp, J.P. (John)
Danoy, P. (Patrick)
Sayers, I. (Ian)
Wilson, S.G. (Scott)
Nethander, M. (Maria)
McCloskey, E.V. (Eugene)
Vandenput, L. (Liesbeth)
Eastell, R. (Richard)
Idzenga, T. (Tim)
Spector, T.D. (Timothy)
Mitchell, B.D. (Braxton)
Streeten, E.A. (Elizabeth)
Brommage, R. (Robert)
Pettersson-Kymmer, U. (Ulrika)
Brown, M.A. (Matthew)
Ohlsson, C. (Claes)
Richards, J.B. (Brent)
Lorentzon, M. (Mattias)
Zheng, H.-F. (Hou-Feng)
Tobias, J.H. (Jon)
Duncan, E.L. (Emma)
Evans, D.M. (David)
Eriksson, J. (Joel)
Paternoster, L. (Lavinia)
Yerges-Armstrong, L.M. (Laura)
Lehtimäki, T. (Terho)
Bergström, U. (Ulrica)
Kähönen, M. (Mika)
Leo, P.J. (Paul)
Raitakari, O. (Olli)
Laaksonen, M. (Marika)
Nicholson, G.C. (Geoffrey)
Viikari, J. (Jorma)
Ladouceur, M. (Martin)
Lyytikäinen, L.-P. (Leo-Pekka)
Medina-Gomez, M.C. (Carolina)
Rivadeneira Ramirez, F. (Fernando)
Prince, R.L. (Richard)
Sievanen, H. (Harri)
Leslie, W.D. (William)
Mellström, D. (Dan)
Eisman, J.A. (John)
Movérare-Skrtic, S. (Sofia)
Goltzman, D. (David)
Hanley, G.E. (Gillian)
Jones, G. (Graeme)
St Pourcain, B. (Beate)
Xiao, Y. (Yanling)
Timpson, N.J. (Nicholas)
Smith, A.V. (Davey)
Reid, I.R. (Ian)
Ring, S.M. (Susan)
Sambrook, P.N. (Philip)
Karlsson, M. (Magnus)
Dennison, E.M. (Elaine)
Kemp, J.P. (John)
Danoy, P. (Patrick)
Sayers, I. (Ian)
Wilson, S.G. (Scott)
Nethander, M. (Maria)
McCloskey, E.V. (Eugene)
Vandenput, L. (Liesbeth)
Eastell, R. (Richard)
Idzenga, T. (Tim)
Spector, T.D. (Timothy)
Mitchell, B.D. (Braxton)
Streeten, E.A. (Elizabeth)
Brommage, R. (Robert)
Pettersson-Kymmer, U. (Ulrika)
Brown, M.A. (Matthew)
Ohlsson, C. (Claes)
Richards, J.B. (Brent)
Lorentzon, M. (Mattias)
Publication Year :
2012

Abstract

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individuals. We then assessed selected single-nucleotide polymorphisms (SNPs) for osteoporotic fracture in

Details

Database :
OAIster
Notes :
application/pdf, PL o S Genetics (Online) vol. 8 no. 7, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn929971364
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1371.journal.pgen.1002745