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Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study
- Publication Year :
- 2010
-
Abstract
- While type 2 diabetes is well-known to be associated with poorer cognitive performance, few studies have reported on the association of metabolic syndrome (MetS) and contributing factors, such as insulin-resistance (HOMA-IR), low adiponectin-, and high C-reactive protein (CRP)- levels. We studied whether these factors are related to cognitive function and which of the MetS components are independently associated. The study was embedded in an ongoing family-based cohort study in a Dutch population. All participants underwent physical examinations, biomedical measurements, and neuropsychological testing. Linear regression models were used to determine the association between MetS, HOMA-IR, adiponectin levels, CRP, and cognitive test scores. Cross-sectional analyses were performed in 1,898 subjects (mean age 48 years, 43% men). People with MetS had significantly higher HOMA-IR scores, lower adiponectin levels, and higher CRP levels. MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women.
Details
- Database :
- OAIster
- Notes :
- European Journal of Epidemiology vol. 25 no. 8, pp. 561-568, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn929963534
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1007.s10654-010-9476-y