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Measurement of hypoxia-related parameters in bronchial mucosa by use of optical spectroscopy.
- Publication Year :
- 2005
-
Abstract
- RATIONALE: Tumor hypoxia has both prognostic and therapeutic consequences for solid tumors. We developed a novel noninvasive technique, differential path-length spectroscopy (DPS), which allows the measurement of hypoxia-related parameters in the superficial microvasculature of tissue. OBJECTIVES: The aim of this study was to measure the microvascular oxygenation of histologically normal endobronchial mucosa and of neoplastic lesions during bronchoscopy using DPS. METHODS: Sixty-four patients with known or suspected malignancies of the lung were studied. One hundred and five endobronchial lesions (38 histologically normal, 37 metaplastic/mild dysplastic lesions, and 30 invasive carcinomas) were detected by white and/or autofluorescence bronchoscopy and measured using DPS. RESULTS: We observed that bronchial tumors are characterized by a lower blood oxygen saturation and a higher blood content than normal mucosa. No differences were observed between normal and metaplastic/mild dysplastic mucosa. CONCLUSION: DPS is a new optical technique allowing the noninvasive study of endobronchial tumor hypoxia.
Details
- Database :
- OAIster
- Notes :
- Bard, M.P.L. (Martin), Amelink, A. (Arjen), Hegt, V.N. (Vincent Noordhoek), Graveland, W.J. (Wilfried), Sterenborg, H.J.C.M. (Dick), Hoogsteden, H.C. (Henk), Aerts, J.G.J.V. (Joachim)
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn929962794
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1164.rccm.200501-046OC