The genes for variant antigens in trypanosomes.

Authors :: Borst, P. (Piet)
Frasch, A.C.C.
Bernards, A. (André)
Hoeijmakers, J.H.J. (Jan)
Ploeg, L.H.T. van der
Cross, G.A.M.
Borst, P. (Piet)
Frasch, A.C.C.
Bernards, A. (André)
Hoeijmakers, J.H.J. (Jan)
Ploeg, L.H.T. van der
Cross, G.A.M.
Publication Year :: 1980
Abstract: We have studied the mechanism of antigenic variation by using DNA complementary to the messenger RNAs for four variant surface glycoproteins of Trypanosoma brucei. Pure complementary DNAs were obtained by cloning as recombinant DNA in Escherichia coli. Using these complementary DNAs as hybridization probes, we have analyzed the genes for these variant surface glycoproteins. The results provide new information on the origin and evolution of antigenic variation, and on the mechanism involved in switching from one antigenic type to another.

Database :: OAIster
Notes :: application/pdf, American Journal of Tropical Medicine and Hygiene vol. 29 no. 5, pp. 1033-1066, English
Publication Type :: Electronic Resource
Accession number :: edsoai.ocn929962453
Document Type :: Electronic Resource