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Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations
Authors :
O'Seaghdha, C.M. (Conall) Wu, H. (Hongsheng) Yang, Q. (Qiong) Kapur, K. (Karen) Guessous, I. (Idris) Zuber, P. (Patrick) Köttgen, A. (Anna) Stoudmann, C. (Candice) Teumer, A. (Alexander) Kutalik, Z. (Zoltán) Mangino, M. (Massimo) Dehghan, A. (Abbas) Zhang, W. (Weihua) Eiriksdottir, G. (Gudny) Li, G. (Guo) Tanaka, T. (Toshiko) Portas, L. (Laura) Lopez, L.M. (Lorna) Hayward, C. (Caroline) Lohman, K. (Kurt) Matsuda, K. (Koichi) Padmanabhan, S. (Sandosh) Firsov, D. (Dmitri) Sorice, R. Ulivi, S. (Shelia) Brockhaus, A.C. (A. Catharina) Kleber, M.E. (Marcus) Mahajan, A. (Anubha) Ernst, F.D.J. (Florian) Gudnason, V. (Vilmundur) Launer, L.J. (Lenore) Mace, A. (Aurelien) Boerwinkle, E.A. (Eric) Arking, D.E. (Dan) Tanikawa, C. (Chizu) Nakamura, Y. (Yusuke) Brown, M.J. (Morris) Gaspoz, J.-M. (Jean-Michel) Theler, J.-M. (Jean-Marc) Siscovick, D.S. (David) Psaty, B.M. (Bruce) Bergmann, S.M. (Sven) Vollenweider, P. (Peter) Vitart, V. (Veronique) Wright, A.F. (Alan) Zemunik, T. (Tatijana) Boban, M. (Mladen) Kolcic, I. (Ivana) Navarro, P. (Pau) Brown, E.M. (Edward) Estrada Gil, K. (Karol) Ding, J. (Jingzhong) Harris, T.B. (Tamara) Bandinelli, S. (Stefania) Hernandez, D.G. (Dena) Singleton, A. (Andrew) Girotto, S. Ruggiero, D. Adamo, P. (Pio) d' Robino, A. (Antonietta) Meitinger, T. (Thomas) Meisinger, C. (Christa) Davies, G. (Gail) Starr, J.M. (John) Chambers, J.C. (John) Boehm, B.O. (Bernhard) Winkelmann, B. Huang, J. (Jian) Murgia, D. (Daniela) Wild, S.H. (Sarah) Campbell, H. (Harry) Morris, A.D. (Andrew) Franco, O.H. (Oscar) Hofman, A. (Albert) Uitterlinden, A.G. (André) Rivadeneira Ramirez, F. (Fernando) Vol̈ker, U. (Uwe) Hannemann, M. (Mario) Biffar, R. (Reiner) Hoffmann, W. (Wolfgang) Shin, S.-Y. Lescuyer, P. (Pierre) Henry, H. (Hughes) Schurmann, C. (Claudia) Munroe, P. (Patricia) Gasparini, P. (Paolo) Pirastu, N. (Nicola) Ciullo, M. Gieger, C. (Christian) März, W. (Winfried) Lind, L. (Lars) Spector, T.D. (Timothy) Smith, A.V. (Davey) Rudan, I. (Igor) Wilson, J.F. (James) Polasek, O. (Ozren) Deary, I.J. (Ian) Pirastu, M. (Mario) Ferrucci, L. (Luigi) Liu, Y. (YongMei) Kestenbaum, B. (Bryan) Kooner, J.S. (Jaspal) Witteman, J.C.M. (Jacqueline) Nauck, M. (Matthias) Kao, W.H.L. (Wen) Wallaschofski, H. (Henri) Bonny, O. (Olivier) Fox, C. (Craig) Bochud, M. (Murielle) O'Seaghdha, C.M. (Conall) Wu, H. (Hongsheng) Yang, Q. (Qiong) Kapur, K. (Karen) Guessous, I. (Idris) Zuber, P. (Patrick) Köttgen, A. (Anna) Stoudmann, C. (Candice) Teumer, A. (Alexander) Kutalik, Z. (Zoltán) Mangino, M. (Massimo) Dehghan, A. (Abbas) Zhang, W. (Weihua) Eiriksdottir, G. (Gudny) Li, G. (Guo) Tanaka, T. (Toshiko) Portas, L. (Laura) Lopez, L.M. (Lorna) Hayward, C. (Caroline) Lohman, K. (Kurt) Matsuda, K. (Koichi) Padmanabhan, S. (Sandosh) Firsov, D. (Dmitri) Sorice, R. Ulivi, S. (Shelia) Brockhaus, A.C. (A. Catharina) Kleber, M.E. (Marcus) Mahajan, A. (Anubha) Ernst, F.D.J. (Florian) Gudnason, V. (Vilmundur) Launer, L.J. (Lenore) Mace, A. (Aurelien) Boerwinkle, E.A. (Eric) Arking, D.E. (Dan) Tanikawa, C. (Chizu) Nakamura, Y. (Yusuke) Brown, M.J. (Morris) Gaspoz, J.-M. (Jean-Michel) Theler, J.-M. (Jean-Marc) Siscovick, D.S. (David) Psaty, B.M. (Bruce) Bergmann, S.M. (Sven) Vollenweider, P. (Peter) Vitart, V. (Veronique) Wright, A.F. (Alan) Zemunik, T. (Tatijana) Boban, M. (Mladen) Kolcic, I. (Ivana) Navarro, P. (Pau) Brown, E.M. (Edward) Estrada Gil, K. (Karol) Ding, J. (Jingzhong) Harris, T.B. (Tamara) Bandinelli, S. (Stefania) Hernandez, D.G. (Dena) Singleton, A. (Andrew) Girotto, S. Ruggiero, D. Adamo, P. (Pio) d' Robino, A. (Antonietta) Meitinger, T. (Thomas) Meisinger, C. (Christa) Davies, G. (Gail) Starr, J.M. (John) Chambers, J.C. (John) Boehm, B.O. (Bernhard) Winkelmann, B. Huang, J. (Jian) Murgia, D. (Daniela) Wild, S.H. (Sarah) Campbell, H. (Harry) Morris, A.D. (Andrew) Franco, O.H. (Oscar) Hofman, A. (Albert) Uitterlinden, A.G. (André) Rivadeneira Ramirez, F. (Fernando) Vol̈ker, U. (Uwe) Hannemann, M. (Mario) Biffar, R. (Reiner) Hoffmann, W. (Wolfgang) Shin, S.-Y. Lescuyer, P. (Pierre) Henry, H. (Hughes) Schurmann, C. (Claudia) Munroe, P. (Patricia) Gasparini, P. (Paolo) Pirastu, N. (Nicola) Ciullo, M. Gieger, C. (Christian) März, W. (Winfried) Lind, L. (Lars) Spector, T.D. (Timothy) Smith, A.V. (Davey) Rudan, I. (Igor) Wilson, J.F. (James) Polasek, O. (Ozren) Deary, I.J. (Ian) Pirastu, M. (Mario) Ferrucci, L. (Luigi) Liu, Y. (YongMei) Kestenbaum, B. (Bryan) Kooner, J.S. (Jaspal) Witteman, J.C.M. (Jacqueline) Nauck, M. (Matthias) Kao, W.H.L. (Wen) Wallaschofski, H. (Henri) Bonny, O. (Olivier) Fox, C. (Craig) Bochud, M. (Murielle)
Publication Year :
2013
Abstract
Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in ≤21,679 additional individuals. Seven l
Details
Database :
OAIster
Notes :
application/pdf, PL o S Genetics (Online) vol. 9 no. 9, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn929959401
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1371.journal.pgen.1003796