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Red blood cells inhibit tumour cell adhesion to the peritoneum

Authors :
Rossen, M.E.E. (Marie Elma) van
Stoop, M.P.O. (M. P O)
Hofland, L.J. (Leo)
Koetsveld, P.M. (Peter) van
Bonthuis, F. (Fred)
Jeekel, J. (Hans)
Marquet, R.L. (Richard)
Eijck, C.H.J. (Casper) van
Rossen, M.E.E. (Marie Elma) van
Stoop, M.P.O. (M. P O)
Hofland, L.J. (Leo)
Koetsveld, P.M. (Peter) van
Bonthuis, F. (Fred)
Jeekel, J. (Hans)
Marquet, R.L. (Richard)
Eijck, C.H.J. (Casper) van
Publication Year :
1999

Abstract

Background: Perioperative blood transfusion has been associated with increased tumour recurrence and poor prognosis in colorectal cancer. Blood loss in the peritoneal cavity might be a tumour-promoting factor for local recurrence. The aim of this study was to investigate whether blood in the peritoneal cavity affects local tumour recurrence. Methods: In an established in vivo rat model the effect of 1.5 ml syngeneic whole blood on tumour cell adhesion and tumour growth was investigated. In the same model the effect of 1.5 ml pure red blood cell (RBC) concentrate and 1.5 ml RBC-derived substances on tumour cell adhesion was studied. In an established in vitro model the effect of increasing numbers of RBCs (0-250 x 10 6) on tumour cell adhesion and tumour growth was assessed. Results: Both the presence of blood and RBC concentrate in the peritoneal cavity prevented tumour cell adhesion in vivo (overall P ≤ 0.001 and P ≤ 0.05 respectively), rather than promoting adherence. RBC concentrate and RBC-derived substances had a comparable inhibitory effect on tumour cell adhesion. In in vitro studies RBCs inhibited tumour cell adhesion but not tumour growth. Conclusion: RBC-derived factors prevent tumour cell adhesion to the peritoneum, and consequently tumour recurrence.

Details

Database :
OAIster
Notes :
application/pdf, British Journal of Surgery vol. 86 no. 4, pp. 509-513, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn929956279
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1046.j.1365-2168.1999.01050.x