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High-throughput epitope identification for snakebite antivenom
- Source :
- Engmark , M , De Masi , F , Laustsen , A H , Gutiérrez , J M , Lomonte , B , Andersen , M R & Lund , O 2015 , ' High-throughput epitope identification for snakebite antivenom ' , The International Sustainability Conference 2015 , Falmer, Brighton , United Kingdom , 25/08/2015 - 28/08/2015 .
- Publication Year :
- 2015
-
Abstract
- Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom. Due to an abundance of snake venom metalloproteinases and phospholipase A2s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families.
Details
- Database :
- OAIster
- Journal :
- Engmark , M , De Masi , F , Laustsen , A H , Gutiérrez , J M , Lomonte , B , Andersen , M R & Lund , O 2015 , ' High-throughput epitope identification for snakebite antivenom ' , The International Sustainability Conference 2015 , Falmer, Brighton , United Kingdom , 25/08/2015 - 28/08/2015 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn927120566
- Document Type :
- Electronic Resource