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Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species
- Publication Year :
- 2012
-
Abstract
- Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB 173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.
Details
- Database :
- OAIster
- Notes :
- text, text, English, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn906796295
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1021.np2009626