Back to Search Start Over

PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer

Authors :
Tse, Brian
Cowin, Gary
Soekmadji, Carolina
Jovanovic, Lidija
Vasireddy, Raja
Ling, Patrick
Khatri, Aparajita
Liu, Tianqing
Thierry, Benjamin
Russell, Pamela
Tse, Brian
Cowin, Gary
Soekmadji, Carolina
Jovanovic, Lidija
Vasireddy, Raja
Ling, Patrick
Khatri, Aparajita
Liu, Tianqing
Thierry, Benjamin
Russell, Pamela
Source :
Nanomedicine
Publication Year :
2015

Abstract

Aim Evaluate potential of newly-developed, biocompatible iron oxide magnetic nanoparticles (MNPs) conjugated with J591, an antibody to an extracellular epitope of prostate specific membrane antigen (PSMA), to enhance MRI of prostate cancer (PCa). Materials & Methods Specific binding to PSMA by J591-MNP was investigated in vitro. MRI studies were performed on orthotopic tumor-bearing NOD.SCID mice 2h and 24hr after intravenous injection of J591-MNPs, or non-targeting MNPs. Results and Conclusions In vitro, MNPs did not affect PCa cell viability, and conjugation to J591 did not compromise antibody specificity and enhanced cellular iron uptake. In vivo, PSMA-targeting MNPs increased MR contrast of tumors, but not by non-targeting MNPs. This provides proof-of-concept that PSMA-targeting MNPs have potential to enhance MR detection/localization of PCa.

Details

Database :
OAIster
Journal :
Nanomedicine
Notes :
application/pdf
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn897574441
Document Type :
Electronic Resource