Reactions of (R-P)- and (S-P)-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with heteroatom nucleophiles; preparation of P-chiral binol phosphinates and related compounds

Reaction of (R-P)- and (S-P)-tert-butylphenylphosphinobromidates and tert-butylphenylthionophosphinochloridates with metallated phenol and BINOL alkoxides, thioalkoxides, amides and enolates leading with clean inversion at phosphorus to phosphinates, phosphinothiolates and phosphinoamidates, and the corresponding thionophosphorus compounds are described. (C) 2001 Elsevier Science Ltd. All rights reserved.