Back to Search
Start Over
Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study
- Source :
- Baslund , B , Tvede , N , Danneskiold-Samsøe , B , Larsson , P , Panayi , G , Petersen , J , Petersen , L J , Beurskens , F J M , Schuurman , J , van de Winkel , J G J , Parren , P W H I , Gracie , J A , Jongbloed , S , Liew , F Y & McInnes , I B 2005 , ' Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study ' , Arthritis & Rheumatism , vol. 52 , no. 9 , pp. 2686-92 .
- Publication Year :
- 2005
-
Abstract
- Interleukin-15 (IL-15) is a proinflammatory, innate response cytokine that mediates pleiotropic effector function in rheumatoid arthritis (RA) inflammatory synovitis. Our objective was to study the ability of HuMax-IL15, a human IgG1 anti-IL-15 monoclonal antibody, to neutralize exogenous and endogenous IL-15 activity in vitro and to perform a phase I-II dose-escalation trial with HuMax-IL15 in patients with active RA.
Details
- Database :
- OAIster
- Journal :
- Baslund , B , Tvede , N , Danneskiold-Samsøe , B , Larsson , P , Panayi , G , Petersen , J , Petersen , L J , Beurskens , F J M , Schuurman , J , van de Winkel , J G J , Parren , P W H I , Gracie , J A , Jongbloed , S , Liew , F Y & McInnes , I B 2005 , ' Targeting interleukin-15 in patients with rheumatoid arthritis: a proof-of-concept study ' , Arthritis & Rheumatism , vol. 52 , no. 9 , pp. 2686-92 .
- Notes :
- English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn889820367
- Document Type :
- Electronic Resource