Tolerance to the Ocular and Cardiovascular Effects of Repeated Low-Level Exposure to Sarin Vapor

Authors :: NATIONAL ACADEMY OF SCIENCES-NATIONAL RESEARCH COUNCIL WASHINGTON DC
Dabisch, P. A.
To, S. D.
Kerut, E. K.
Miller, D. B.
Burnett, D. C.
Jakubowski, E. M.
Muse, W. T.
Davis, E. A.
Benton, B. J.
Hulet, S. W.
NATIONAL ACADEMY OF SCIENCES-NATIONAL RESEARCH COUNCIL WASHINGTON DC
Dabisch, P. A.
To, S. D.
Kerut, E. K.
Miller, D. B.
Burnett, D. C.
Jakubowski, E. M.
Muse, W. T.
Davis, E. A.
Benton, B. J.
Hulet, S. W.
Source :: DTIC AND NTIS
Publication Year :: 2004
Abstract: Inhibition of acetylcholinesterase (AChE) by the nerve agent sarin (GB) results in accumulation of acetylcholine and excessive cholinergic stimulation. Little data exists in the literature regarding the effects of low-level repeated exposure to GB vapor. In the present study male rats were exposed to multiple low-level inhalation exposures to GB vapor. The data from the present study demonstrate that multiple inhalation exposures to GB vapor result in tolerance to the ocular and autonomic effects of GB vapor. While the observed decrease in the potency of GB in rats cannot he attributed to a reduction in the inhibitory effect of GB additional experiments are needed to determine the exact mechanism of the tolerance observed.<br />See also ADM001736, Proceedings for the Army Science Conference (24th) held on 29 November - 2 December 2004 in Orlando, Florida.

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