Task 89-06: Determination of the Bioequivalence of HI-6 and Atropine When Delivered by Wet/Dry Autoinjector or Syringe in Sheep: A Pharmacokinetic and Efficacy Evaluation

A study was instituted in sheep to compare efficacy against Soman and the pharmacokinetics of atropine and HI-6 by wet/dry autoinjector and by syringe. The efficacy in sheep against Soman of Atropine/HI-6 delivered by wet/ dry autoinjector was also compared to the efficacy of atropine/pralidoxime chloride when syringe. The aging rate of GD was also determined in sheep erytrocytes. There were no statistical differences in the LD50's of sheep treated with atropine/HI-6 using syringes of wet/dry autoinjectors. A PR was determined for atropine/HI-6 treatment. Based on analyses of HI-6 and atropine pharmacokinetic parameters there were no statistically significant differences in the two injection techniques. The aging rate of sheep RBC's is highly dependent upon the GD-AChE incubation temperature.