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Purinergic Receptors in Quiescence and Localization of Leukemic Stem Cells

Authors :
PITTSBURGH UNIV PA
Lee, Byeong-Chel
PITTSBURGH UNIV PA
Lee, Byeong-Chel
Source :
DTIC
Publication Year :
2011

Abstract

A small subpopulation of drug- and radiation-resistant leukemia is an immediate concern for leukemia patients as this subtype remains the actual cause of morbidity and mortality. Our preliminary results showed that P2Y14 functions in bone marrow to preserve stem progenitor cells from premature senescence/cell death induced by genotoxic stress. As P2Y14 is highly expressed in differentiation resistant leukemia cells, P2Y14 expression in leukemia cells may function in preserving regenerative capacity by constraining cell death/senescence induction. We also found that P2Y14 axis is associated with stem cell mobilization. By providing a mechanistic insight for the roles of P2Y14 in the genotoxic stress-induced injury, directly documenting the effects of P2Y14/UDP-Glc axis on stem cell mobilization, our preliminary results are expected to provide the foundation for an effective treatment to destroy therapy resistant leukemia cells.<br />The original document contains color images.

Details

Database :
OAIster
Journal :
DTIC
Notes :
text/html, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn832132459
Document Type :
Electronic Resource