Evaluation of a Test Article in the Salmonella typhimurium/Ecscherichia coli Plate Incorporation Mutation Assay in the Presence and Absence of Induced Rat Liver S-9. Test Article - Diethylene triamine trinitrate (DETN)

Diethylene triamine trinitrate (DETN) (100% pure) was tested for mutagenic potentials with Salmonella typhimurium strains, TA 98, TA 100, TA 1535, TA 1537 and Escherichia coli strain WP2 uvrA by plate incorporation method according to OECD TG 471 in compliance with Good Laboratory Practice. The results showed that DETN was not mutagenic in Salmonella typhimurium and Escherichia coli both with and without activation at concentration of 100, 500, 1000, 3000, and 5000 ug/plate with and without activation.