Genomic Instability and Breast Cancer

We are investigating the regulation of genomic stability and how the disruption of such regulation contributes to breast cancer development. We have performed in-depth studies of BRCA1 and the DNA damage response, which allow us to propose a new model of DNA damage signaling pathways and how it functions to ensure genomic stability in response to DNA damage. In addition, we are continuing our purification of protein complexes for the study of cell cycle and DNA damage networks involved in breast cancer development. We have identified several new components involved in DNA damage repair or mitotic progression. While some of these studies are still ongoing, we have already made several exciting findings and published some of them recently. We hope that these studies will help us to understand breast cancer etiology and discover new targets for cancer treatment.