ANTIHEMAGGLUTINATING ANTIBODY SPECTRUM FOLLOWING EXPERIMENTAL IMMUNIZATION WITH TICK-BORNE ENCEPHALITIS VIRUSES

A study was made of the regularities of formation and the dynamics of homologous and heterologous antihemagglutinins, developing after immunization of animals with the eastern and western strains of tick-borne encephalitis and the viruses of Scotland encephalomyelitis of sheep, Omsk hemorrhagic fever, Kyasanur forest disease, Langat, Powassan and Negishi. The differences in the dynamics of homologous and heterologous antihemagglutinins after hypo- and hyperimmunization and reimmunization bear a quantitative nature. Immunization with any strain of tick-borne encephalitis virus leads to the formation of antihemagglutinating antibodies on an equal level to all the remaining strains related to this virus. There is a simultaneous formation of antibodies to all the other representatives of this group, but in lower titers. For the viruses of Omsk hemorrhagic fever, Langat, Scotland encephalomyelitis of sheep and Negishi the difference in titers of antibodies reach large differences, if the antibodies are determined against the viruses of Kyasanur forest disease (3--5 log) and especially Powassan (5--7 log). Immunization with any other virus of the subgroup, except Powassan, also leads to the appearance of antibodies to the remaining representatives of the complex. The titers of antibodies here are lower by 1--3 log than to the homologous virus.
Trans. of Voprosy Virusologii (USSR), v10 n6 p657-63 1965.