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POTENTIAL ANTIMALARIALS STRUCTURALLY RELATED TO QUININE.
- Source :
- DTIC AND NTIS
- Publication Year :
- 1969
-
Abstract
- The base-catalyzed condensation of 3-quinuclidinone with quinoline carboxaldehydes provides easy access to a large number of compounds which may be loosely described as desvinylquinine derivatives. Many such substances have been synthesized and submitted for antimalarial screening. Of particular interest are the quinolinemethanols obtained by acid-catalyzed hydration of the condensation products. The unique metal complexes of 2-(2'-quinolyl)methylene-3-quinuclidinone which were encountered during this work and progress on an attempt to synthesize the complete quinine skeleton are also described. (Author)
Details
- Database :
- OAIster
- Journal :
- DTIC AND NTIS
- Notes :
- text/html, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn831485884
- Document Type :
- Electronic Resource