MATHEMATICAL THEORY OF MOLECULAR CONTROL SYSTEMS.

The major emphasis of this report is related to problems associated to theory and mechanism of blood clotting. The first study relates to the thermodynamics of protein adsorption onto surfaces. This study provides a uniform theory of the interaction between proteins and surfaces which takes into account both surface energy and surface charge among other factors. Further studies were undertaken of the mathematical treatment of the cascade theory of blood coagulation, taking into account the regulation provided by negative feedback mechanisms. This work provides an important extension of our earlier studies. Other studies related to bio-electrodes with reference to their applications in energy conversion in physiological environment and as sensing devices. (Author)
Prepared in cooperation with State Univ. of New York, Stony Brook.