AUTOMATIC RECORDING OF PO2, PH, NA AND K IN THE BLOOD AND THE BRAIN.

The effect of intravenous administration of concentrated Na and K solutions, and cardiorespiratory stimulants on cerebral circulation, metabolism and electrical activity were investigated in cats. (1) Effect of concentrated cation solutions: (a) Increased Na(+) in the extracellular fluids of the brain induced the electrical and metabolic activation and increase in cerebral blood flow. Electroencephalogram showed the seizure or low voltage fast activity. Cerebral blood flow increased, brain PO2 and PCO2 increased, pH decreased, Na(+) usually increased and when seizure started Na(+) changed to decrease. (b) Intravenous administration of concentrated K solution resulted in the cardiac dysfunction and consequently showed a decrease in cerebral blood flow and metabolism, and electrical depression. After intracisternal administration of concentrated K solution, it appeared to show the metabolic and electrical activation. However, since there is a question about increase in concentration of K+ in the brain surface after intracisternal administration of K, further investigation with more appropriate method is necessary for obtaining the direct action of K+ on the brain. (2) Effect of intravenous administration of cardiorespiratory stimulants of aminophylline, dimorpholamine, nikethamide, vitacampher and lobeline were investigated. (Author)
See also AD-438 200.