レチノイドによるサイトカイン受容体発現調節を介した癌細胞サイトカイン感受性の制御

平成13年度-平成15年度年度科学研究費補助金 (基盤研究(B)(1) 課題番号13557048) 研究成果報告書
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13-19p: Moriwaki H. , Prevention of liver cancer: basic and clinical aspects. Experimental and molecular medicine. 2002 34(5): 319-325
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29-40p: Yasuda I. et al., Acyclic retinoid induces partial differentiation, down-regulates telomerase reverse transcriptase mRNA expression and telomerase activity, and induces apoptosis in human hepatoma-derived cell lines. Journal of Hepatology. 2002 36: 660-671
41-50p: Obora A. et al., Synergistic Induction of Apoptosis by Acyclic Retinoid and Interferon-β in Human Hepatocellular Carcinoma Cells. Hepatology. 2002 36(5): 1115-1124
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66-78p: Okuno M. et al., Retinoids in Liver Fibrosis: Induction of Proteolytic Activation of Transforming Growth Factor-β by Retinoic Acid and Its Therapeutic Control by Protease Inhibitors. Extracellular Matrix and the Liver. 2003 : 391-403
79-89p: Suzui M. et al., Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of β-catenin mutation. Cancer Letters. 2002 183: 31-41
90-96p: Suzui M. et al., Different Mutation Status of the β-Catenin Gene in Carcinogen-Induced Colon, Brain, and Oral Tumors in Rats. Molecular Carcinogenesis. 2001 32: 206-212
97-109p: Akita K. et al., Impaired Liver Regeneration in Mice by Lipopolysaccharide Via TNF-α/Kallikrein-Mediated Activation of Latent TGF-β. Gastroenterology. 2002 123: 352-364
110-115p: Fukutomi Y. et al., Metachronous colon tumors: risk factors and rationale for the surveillance colonoscopy after initial polypectomy. Journal of Cancer Research and Clinical Oncology. 2002 128: 569-574
116-123p: Matsushima-Nishiwaki R. et al., Phosphorylation of Retinoid X Receptor α at Serine 260 Impairs Its Metabolism and Function in Human Hepatocellular Carcinoma. Cancer Research. 2001 61: 7675-7682
124-130p: Okuno M. et al., Chemoprevention of hepatocellular carcinoma: Concept, progress and perspectives. Journal of Gastroenterology and Hepatology. 2001 16: 1329-1335
131-134p: Okuno M. et al., Apoptosis Induction by Acyclic Retinoid: a Molecular Basis of 'Clonal Deletion' Therapy for Hepatocellular Carcinoma. Japanese Journal of Clinical Oncology. 2001 31(8): 359-362
135-141p: Okuno M. et al., Retinoid-Induced Apoptosis in Hepatocellular Carcinoma: A Molecular Basis for "Clonal Deletion" Therapy. Frontiers in Hepatology. 2002: 33-39
142-158p: Okuno M. et al., Prevention of Rat Hepatic Fibrosis by the Protease Inhibitor, Camostat Mesilate, via Reduced Generation of Active TGF-β. Gastroenterology . 2001 120: 1784-1800
159-166p: Shimizu M. et al., Mechanism of Retarded Liver Regeneration in Plasminogen Activator-Deficient Mice: Impaired Activation of Hepatocyte Growth Factor After Fas-Mediated Massive Hepatic Apotosis. Hepatology. 2001 33(3): 569-576
167-169p: Okuno M. et al., Protease Inhibitors: Suppression of Activation of Hepatic Stellate Cells by Inhibiting TGFβ Generation. Trends in Gastroenterology and Hepatology. 2001: 361-363