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Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients.
- Source :
- Clinical cancer research, 15 (10
- Publication Year :
- 2009
-
Abstract
- A critical factor determining the effectiveness of currently used dendritic cell (DC)-based vaccines is the DC activation or maturation status. We have recently shown that the T-cell stimulatory capacity of DCs pulsed with tumor-antigen-derived peptides can be considerably increased by activating the DCs through electroporation with mRNA encoding CD40 ligand, CD70, and a constitutively active Toll-like receptor 4 (TriMix DCs). Here, we investigate whether TriMix DCs can be coelectroporated with whole tumor-antigen-encoding mRNA.<br />Journal Article<br />Research Support, Non-U.S. Gov't<br />info:eu-repo/semantics/published
Details
- Database :
- OAIster
- Journal :
- Clinical cancer research, 15 (10
- Notes :
- 1 full-text file(s): application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn803509242
- Document Type :
- Electronic Resource